The Pressure-Volume Relation

  • Nicolaas Westerhof
  • Nikolaos Stergiopulos
  • Mark I. M. Noble


Otto Frank studied pressure-volume relations in the isolated frog heart. He found different End-Systolic Pressure-Volume Relations, ESPVR’s, for the ejecting heart and the isovolumically contracting heart. In other words, a single unique End-Systolic Pressure-Volume Relation did not appear to exist.


Diastolic Dysfunction Diastolic Filling Lumen Volume Increase Wall Thickness Eccentric Hypertrophy 
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Copyright information

© Springer US 2010

Authors and Affiliations

  • Nicolaas Westerhof
    • 1
  • Nikolaos Stergiopulos
    • 2
  • Mark I. M. Noble
    • 3
  1. 1.Departments of Physiology and Pulmonology ICaR-VUVU University Medical CenterAmsterdamthe Netherlands
  2. 2.Laboratory of Hemodynamics and Cardiovascular TechnologySwiss Federal Institute of TechnologyLausanneSwitzerland
  3. 3.Cardiovascular MedicineAberdeen UniversityAberdeenScotland

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