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Membrane Association and Pore Formation by Alpha-Helical Peptides

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 677)

Abstract

Membrane-active peptides exhibit antimicrobial, channel-forming and transport activities and have therefore early on been interesting targets for biophysical investigations. When the peptide-lipid interactions are studied a dynamic view emerges in which the peptides change conformation upon membrane insertion, can adopt a variety of topologies and change the macroscopic phase properties of the membrane locally or globally. Interestingly several proteins have been identified that also interact with the membrane in a dynamic fashion and where the lessons learned from peptides may add to our understanding of the ways these proteins function.

Keywords

Lipid Bilayer Antimicrobial Peptide Pore Formation Membrane Association Membrane Insertion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Institut de chimieCNRS—Université de StrasbourgStrasbourgFrance

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