Chemo Fog pp 119-123 | Cite as

The Possible Role of Cytokines in Chemotherapy-Induced Cognitive Deficits

  • Jamie S. Myers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 678)

Abstract

Proinflammatory cytokines play a significant role in the body’s immune response to pathogens, including malignant cells. Proinflammatory cytokines are associated with tumor invasion and progressive disease and are released in response to many antineoplastic agents. Exogenous administration and endogenous production of cytokines is related to a pattern of behaviors known as sickness behavior that has a significant impact on patients’ quality of life. The behavioral patterns associated with sickness behavior include inability to concentrate and impaired learning. Identification of sequelae specific to individual cytokine activity provides novel targets for investigation.

Keywords

Fatigue Depression Oncol Doxorubicin Docetaxel 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Maier SF, Watkins LR. Immune-to-central nervous system communication and its role in modulating pain and cognition: implications for cancer and cancer treatment. Brain Behav Immun 2003; 17(Suppl 1):S125–131.PubMedCrossRefGoogle Scholar
  2. 2.
    Miller AH. Cytokines and sickness behavior: implications for cancer care and control. Brain Behav Immun 2003; 17:S132–134.PubMedCrossRefGoogle Scholar
  3. 3.
    Niiya M, Niiya K, Kiguchi T et al. Induction of TNF-alpha, uPA, IL-8 and MCP-1 by doxorubicin in human lung cancer cells. Cancer Chemother Pharmacol 2003; 52:391–398.PubMedCrossRefGoogle Scholar
  4. 4.
    Wichmann MW, Meyer G, Adam M et al. Detrimental immunologc efects of preoperative chemoradiotherapy in advanced rectal cancer. Dis Colon Rectum 2003; 46:875–887.PubMedCrossRefGoogle Scholar
  5. 5.
    Zaks-Zilberman M, Zaks TZ, Vogel SN. Induction of proinflammatory and chemokine genes by lipopolysaccharide and paclitaxel (Taxol) in murine and human breast cancer cell lines. Cytokine 2001; 15(3):156–165.PubMedCrossRefGoogle Scholar
  6. 6.
    Hart BL. Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988; 12(2):123–137.PubMedCrossRefGoogle Scholar
  7. 7.
    Wood LJ, Nail LM, Gilster A et al. Cancer chemotherapy-related symptoms: Evidence to suggest a role for proinflammatory cytokines. Oncolog Nursing Forum 2006; 33:535–542.CrossRefGoogle Scholar
  8. 8.
    Decker J. Cytokines. 2006. http://www.microvet.arizona.edu/courses/MIC419/Tutorials/cytokines.html. Accessed 2009.Google Scholar
  9. 9.
    Maier SF, Watkins LR. Cytokines for psychologists: implications of bi-directional immune-to-brain communication for understanding behavior, mood and cognition. Psychology Review 1998; 105(1):83–107.CrossRefGoogle Scholar
  10. 10.
    Ebrahimi B, Tucker SL, Li D et al. Cytokines in pancreatic carcinoma: Correlation with phenotypic characteristics and prognosis. Cancer 2004; 101:2727–2736.PubMedCrossRefGoogle Scholar
  11. 11.
    Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry 2000; 157(5):683–694.PubMedCrossRefGoogle Scholar
  12. 12.
    Lee B, Dantzer R, Langley KE et al. A cytokine-based neuroimmunologic mechanism of cancer-related symptoms. Neuroimmunomodulation 2004; 11:279–282.PubMedCrossRefGoogle Scholar
  13. 13.
    Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7:211–217.PubMedCrossRefGoogle Scholar
  14. 14.
    Cleeland CS, Bennett GJ, Dantzer R et al. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immonologic model of cancer symptoms. Cancer 2003; 97:2919–2925.PubMedCrossRefGoogle Scholar
  15. 15.
    Maier SF. Bi-directional immune-brain communication: implications for understanding stress, pain and cognition. Brain Behav Immun 2003; 17(2):69–85.PubMedCrossRefGoogle Scholar
  16. 16.
    Ahles TA, Saykin A. Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 2007; 7:192–201.PubMedCentralPubMedCrossRefGoogle Scholar
  17. 17.
    Chen Y, Jungsuwadee P, Vore M et al. Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues. Mol Interv 2007; 7(3):147–155.PubMedCrossRefGoogle Scholar
  18. 18.
    Tangpong J, Cole MP, Sultana R et al. Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: Insight into the mechanism of chemobrain. J Neurochem 2007; 100(1):191–201.PubMedCrossRefGoogle Scholar
  19. 19.
    Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci 2001; 933:222–234.PubMedCrossRefGoogle Scholar
  20. 20.
    Harvey PO, Pruessner J, Czechowska Y et al. Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in nonclinical subjects. Mol Psychiatry 2007; Epub ahead of print.Google Scholar
  21. 21.
    Pollmacher T, Haack M, Schuld A et al. Low levels of circulating inflammatory cytokines-do they affect human brain functions? Brain Behav Immun 2002; 16:525–532.PubMedCrossRefGoogle Scholar
  22. 22.
    De La Garza R. Endotoxin-or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia. Neurosci Biobehav Rev 2005; 29:761–770.CrossRefGoogle Scholar
  23. 23.
    Johnson RW. The concept of sickness behavior: a brief chronological account of four key discoveries. Vet Immunol Immunopathol 2002; 87(3–4):443–450.PubMedCrossRefGoogle Scholar
  24. 24.
    Haddad JJ, Saade NE, Safieh-Garabedian B. Cytokines and neuro-immune endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axis. J Neuroimmunol 2003; 133(1–2):1–19.Google Scholar
  25. 25.
    Larson SJ. Behavioral and motivational effects of immune-system activation. J Gen Psychol 2002; 129(4):401–414.PubMedCrossRefGoogle Scholar
  26. 26.
    Kelley KW, Bluthe RM, Dantzer R et al. Cytokine-induced sickness behavior. Brain Behav Immun 2003; 17(Suppl 1):S112–118.PubMedCrossRefGoogle Scholar
  27. 27.
    Dantzer R. Cytokine-induced sickness behavior: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 2004; 500(1–3):399–411.PubMedCrossRefGoogle Scholar
  28. 28.
    Illman J, Corringham R, Robinson D et al. Are inflammatory cytokines the common link between cancer-associated cachexia and depression? J Support Oncol 2005; 3(1):37–50.PubMedGoogle Scholar
  29. 29.
    Barsevik AM. The elusive concept of the symptom cluster. Oncol Nurs Forum 2007; 34:971–980.CrossRefGoogle Scholar
  30. 30.
    Dodd M, Miaskowski C, Paul SM. Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum 2001; 28:465–470.PubMedGoogle Scholar
  31. 31.
    Kim HJ, McGuire DB, Tulman L. Symptom clusters: Concept analysis and clinical implications for cancer nursing. Cancer Nurs 2005; 28:270–282.PubMedGoogle Scholar
  32. 32.
    Fleishman SB. Treatment of symptom clusters: Pain, depression and fatigue. J Natl Cancer Inst Monogr. 2004;(32):119–23.PubMedCrossRefGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Jamie S. Myers
    • 1
  1. 1.School of NursingUniversity of KansasKansas CityUSA

Personalised recommendations