Chemo Fog pp 119-123 | Cite as

The Possible Role of Cytokines in Chemotherapy-Induced Cognitive Deficits

  • Jamie S. Myers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 678)


Proinflammatory cytokines play a significant role in the body’s immune response to pathogens, including malignant cells. Proinflammatory cytokines are associated with tumor invasion and progressive disease and are released in response to many antineoplastic agents. Exogenous administration and endogenous production of cytokines is related to a pattern of behaviors known as sickness behavior that has a significant impact on patients’ quality of life. The behavioral patterns associated with sickness behavior include inability to concentrate and impaired learning. Identification of sequelae specific to individual cytokine activity provides novel targets for investigation.


Blood Brain Barrier Cytokine Release Antineoplastic Agent Symptom Cluster Sickness Behavior 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Jamie S. Myers
    • 1
  1. 1.School of NursingUniversity of KansasKansas CityUSA

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