Part of the Developmental Psychopathology at School book series (DPS)


Previous chapters delineate the prevalence rates and trajectories for young people diagnosed with early-onset schizophrenia (EOS), theoretical orientations to understand its origins and development, as well as assessment strategies for screening, diagnosis, and psychoeducational purposes. EOS presents a complex challenge for mental health professionals in terms of its defining characteristics, and this complexity carries over to accompanying treatments. Because symptoms typically develop gradually, by the time affected children are referred for treatment, they may present severe characteristics of the disorder. Moreover, multiple inaccurate diagnoses may have been proffered before the correct identification occurs (Frazier et al., 2007; Schaeffer & Ross, 2002). As such, valuable time may have been lost in which an effective treatment approach could have been implemented.


Cognitive Behavioral Therapy Negative Symptom Antipsychotic Medication Psychosocial Intervention Assertive Community Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. American Academy of Child and Adolescent Psychiatry (2001). Practice parameter for the assessment and treatment of children and adolescents with schizophrenia, Journal of the American Academy of Child and Adolescent Psychiatry, 40, 5s–23s.CrossRefGoogle Scholar
  2. Amminger, G.P., Paper, S., Rock, D., Roberts, S.A., Ott, S.L., & Squires-Kimling, I. (1999). Relationship between childhood behavioral disturbance and later schizophrenia in the New York High-Risk project. American Journal of Psychiatry, 156, 525–530.PubMedGoogle Scholar
  3. Armenteros, J.L., & Davies, M. (2006). Antipsychotics in early-onset schizophrenia: Systematic review and meta-analysis. European Child and Adolescent Psychiatry, 15, 14–148.CrossRefGoogle Scholar
  4. Asarnow, J.R., Thompson, M.C., & McGrath, E.P. (2004). Annotation: Childhood-onset schizophrenia: Clinical and treatment issues. Journal of Child Psychology and Psychiatry, 45, 180–194.PubMedCrossRefGoogle Scholar
  5. Ayuso-Gutierrez, J.L., & del Rio, V. (1997). Factors influencing relapse in the long-term course of schizophrenia. Schizophrenia Research, 28, 199–206.PubMedCrossRefGoogle Scholar
  6. Bandura, A. (1977). Social Learning Theory. London: Prentice Hall.Google Scholar
  7. Benton, M.K., & Schroeder, H.E. (1990). Social skills training with schizophrenics: A meta-analytic evaluation. Journal of Consulting and Clinical Psychology, 58, 741–747.PubMedCrossRefGoogle Scholar
  8. Brown, R.T., Antonuccio, D.O., DuPaul, G.J., Fristad, M.A., King, C.A., Leslie, L.K., & Vitiello, B. (2008). Childhood mental health disorders: Evidence base and contextual factors for psychosocial, psychopharmacological, and combined interventions. Washington, DC: American Psychological Association.CrossRefGoogle Scholar
  9. Bruns, E (2008). The evidence base and wraparound. In E.J. Bruns & J.S. Walker (Eds.), The resource guide to wraparound. Portland, OR: National Wraparound Initiative, Research and Training Center for Family Support and Children’s Mental Health.Google Scholar
  10. Bryden, K.E., Carrey, N.J., & Kutcher, S.P. (2001). Update and recommendations for the use of antipsychotics in early-onset psychoses, Journal of Child and Adolescent Psychopharmacology, 11, 113–130.PubMedCrossRefGoogle Scholar
  11. Burns, B.J., & Santos, A.B. (1995). Assertive community treatment: an update of randomized trials. Psychiatric Services, 46, 669–675.PubMedGoogle Scholar
  12. Castro-Fornieles, J., Parellada, M., Soutullo, C.A., Baeza, I., Gonzalez-Pinto, A., Graell, M., & Arango, C. (2008). Antipsychotic treatment in child and adolescent first-episode psychosis: A longitudinal naturalistic approach. Journal of Child and Adolescent Psychopharmacology, 18, 327–336.PubMedCrossRefGoogle Scholar
  13. Clark, A.F., & Lewis, S.W. (1998). Practitioner review: Treatment of schizophrenia in childhood and adolescence, Journal of Child Psychology and Psychiatry, 39, 1071–1081.PubMedCrossRefGoogle Scholar
  14. Coleman, R. (1973). A procedure for fading from experimenter-school based to parent-home based control of classroom behavior. Journal of School Psychology, 11, 71–79.CrossRefGoogle Scholar
  15. Davidson, L., Stayner, D., & Haglund, K.E. (1998). Phenomological perspectives on the social functioning of people with schizophrenia. In K.T. Mueser & N. Tarrier (Eds.), Handbook of Social Functioning in Schizophrenia (pp.97–120). Needham Heights, MA: Allyn and Bacon.Google Scholar
  16. Dickerson, F.B. (2000). Cognitive behavioral psychotherapy for schizophrenia: A review of recent empirical studies. Schizophrenia Research, 16, 71–90.CrossRefGoogle Scholar
  17. Dickerson, F.B., Tenhula, W.N., & Green-Paden, L.D. (2005). The token economy for schizophrenia: Review of the literature and recommendations for future research. Schizophrenia Research, 75, 405–416.PubMedCrossRefGoogle Scholar
  18. Dilk, M.N., & Bond, G.R. (1996). Meta-analytic evaluation of skills training research for individuals with severe mental illness: Review of recent studies. Journal of Consulting and Clinical Psychology, 64, 1337–346.PubMedCrossRefGoogle Scholar
  19. Dixon, L.B., Lehman, A.F., & Levine, J. (1995). Conventional antipsychotic medications for schizophrenia. Schizophrenia Bulletin, 4, 567–577.CrossRefGoogle Scholar
  20. Doane, J.A., Goldstein, M.J., Miklowitz, D.J., & Falloon, I.R.H. (1986). The impact of individual and family treatment on the affective climate of families of schizophrenics. British Journal of Psychiatry, 148, 279–287.PubMedCrossRefGoogle Scholar
  21. Drury, B., Birchwood, M., & Cochrane, R. (2000).Cognitive therapy and recovery form acute psychosis: A controlled trial III. Five-year follow-up. British Journal of Psychiatry, 177, 8–14.PubMedCrossRefGoogle Scholar
  22. Dulmus, C.N., & Smyth, N.J. (2000). Early-onset schizophrenia: A literature review of empirically based interventions. Child and Adolescent Social Work Journal, 17, 55–69.CrossRefGoogle Scholar
  23. Eber, L., Sugai, G., Smith, C.R., & Scott, T.M. (2002). Wraparound and positive behavioral interventions and supports in the schools. Journal of Emotional and Behavioral Disorders, 10, 171–180.CrossRefGoogle Scholar
  24. Erhart, S.M., Marder, S.R., & Carpenter, W.T. (2006). Treatment of schizophrenia negative symptoms: Future prospects. Schizophrenia Bulletin, 32, 234–237.PubMedCrossRefGoogle Scholar
  25. Fenton, W.S., Blyler, C.R., & Heinssen, R.K., (1997). Determinants of medication compliance in schizophrenia: Empirical and clinical findings. Schizophrenia Bulletin, 23, 637–651.PubMedCrossRefGoogle Scholar
  26. Findling, R.L., Robb, A., Nyilas, M., Forbes, R.A., Jin, N., & Ivanova, S., et al. (2008). A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia. American Journal of Psychiatry, 165, 1432–1441.PubMedCrossRefGoogle Scholar
  27. Findling, R.L., & Schulz, S.C. (2005). Juvenile-Onset Schizophrenia: Assessment, Neurobiology, and Treatment. Baltimore, MD: John Hopkins Press.Google Scholar
  28. Frazier, F.A., McClellan, J., Findling, R.L., Vitiello, B., Anderson, R., Zablotsky, B., et al. (2007). Treatment of early-onset schizophrenia spectrum disorders (TEOSS): Demographic and clinical characteristics. Journal of American Academy of Child and Adolescent Psychiatry, 46, 979–988.CrossRefGoogle Scholar
  29. Garety, P.A., Fowler, D., & Kuipers, E. (2000). Cognitive-behavioral therapy for medication-resistant symptoms. Schizophrenia Bulletin, 26, 73–86.PubMedCrossRefGoogle Scholar
  30. Garety, P.A., & Freeman, D. (1999). Cognitive approaches to delusions: A critical review of theories and evidence. British Journal of Clinical Psychology, 38, 113–154.PubMedCrossRefGoogle Scholar
  31. Goldstein, M.J., & Miklowitz, D.J. (1995). The effectiveness of psychoeducational family therapy in the treatment of schizophrenic disorders. Journal of Marital and Family Therapy, 21, 361–376.CrossRefGoogle Scholar
  32. Gonthier, M., & Lyon, M.A. (2004). Childhood-onset schizophrenia: An overview. Psychology in the Schools, 41, 803–811.CrossRefGoogle Scholar
  33. Haugaard, J.J. (2004). Recognizing and treating rare behavioral and emotional disorders in children and adolescents who have been severely maltreated: Schizophrenia. Child Maltreatment, 9, 161–168.PubMedCrossRefGoogle Scholar
  34. Hogarty, G.E. (2002). Personal therapy: A practical psychotherapy for stabilization of schizophrenia. In S.G. Hoffman & M.C. Tompson (Eds.), Treating Chronic and Severe Mental Disorders: A Handbook of Empirically-Supported Interventions. New York: Guilford Press.Google Scholar
  35. Hogarty, G.E., & Ulrich, R.F. (1998). The limitations of antipsychotic medications on schizophrenia relapse and adjustment and the contributions of psychosocial treatment. Journal of Psychiatric Research, 32, 243–250.PubMedCrossRefGoogle Scholar
  36. Kazdin, A.E., & Bootzin, R.R. (1972). The token economy: An evaluative review. Journal of Applied Behavioral Analysis, 5, 343–372.CrossRefGoogle Scholar
  37. Kelsey, J.E., Newport, D.J., & Nemeroff, C. B. (2006). Principles of Psychopharmacology for Mental Health Professionals. John Wiley & Sons, Inc.CrossRefGoogle Scholar
  38. Kendziora, K., Bruns, E., Osher, D., Pacchiano, D., & Mejia, B. (2001). Systems of Care: Promising Practices in Children’s Mental Health, 2001 Series, Volume 1. Washington, D.C.: Center for Effective Collaboration and Practice, American Institutes for Research.Google Scholar
  39. Kranzler, H., Roofeh, D., Gerbino-Rosen, G., Dombrowski, C., McMeniman, M., & DeThomas, C., et al. (2005). Clozapine: Its impact on aggressive behavior among children and adolescents with schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 55–63.PubMedCrossRefGoogle Scholar
  40. Kronenberger, W.G., & Meyer, R.G. (2001). The Child Clinician’s Handbook (Second Edition). Boston: Allyn and Bacon.Google Scholar
  41. Lehman, A.F., Kreyenbuhl, J., Buchanan, R.W., Dickerson, F.B., Dixon, L.B., Goldberg, R., &Steinwachs, D.M. (2004). The Schizophrenia Patient Outcomes Research Team (PORT): Updated treatment recommendations 2003. Schizophrenia Bulletin, 30, 193–217.PubMedCrossRefGoogle Scholar
  42. Margari, F., Presicci, A., Petruzzelli, M.G., Ventura, P., Di Cuonzo, F., & Palma, M., et al. (2008). Very early onset and greater vulnerability in schizophrenia: A clinical and neuroimaging study. Neuropsychiatric Disease and Treatment, 4, 825–830.PubMedCrossRefGoogle Scholar
  43. Matson, J.L., & Boisjoli, J.A. (2009). The token economy for children with intellectual disability and/or autism: A review. Research in Developmental Disabilities, 30, 240–248.PubMedCrossRefGoogle Scholar
  44. McFarlane, W.R., Lukens, E., Link, B., Dushay, R., Deakins, S.A., Newmark, M., & Toran, J. (1995). Multiple-family groups and psychoeducation in the treatment of schizophrenia. Archives of General Psychiatry, 52, 679–687.PubMedCrossRefGoogle Scholar
  45. Mozes, T., Greenberg, Y., Spivak, B., Tyano, S., Weizman, A., & Mester, R. (2003). Olanzapine treatment in chronic-drug resistant childhood-onset schizophrenia: An open-label study. Journal of Child and Adolescent Psychopharmacology, 13, 311–317.PubMedCrossRefGoogle Scholar
  46. Mueser, K., & Bond, G.R. (2000). Psychosocial treatment approaches for schizophrenia. Current Opinion in Psychiatry, 13, 27–35.CrossRefGoogle Scholar
  47. Nicolson, R., Brookner, F. B., Lenane Gochman, P., Ingraham, L.J., Egan, M.F., & Rapoport, J.L. (2003). Parental schizophrenia spectrum disorders in childhood-onset and adult on-set schizophrenia. American Journal of Psychiatry, 160, 490–495.PubMedCrossRefGoogle Scholar
  48. Paul, G.L., & Lentz, R.J. (1977). Psychosocial treatment of chronic mental patients: milieu versus social learning programs. Cambridge, Mass, Harvard University Press.Google Scholar
  49. Penn, D.L., Mueser, K.T., Tarrier, N., Gloege, A., Cather, C., Serrano, D., & Otto, M.W. (2004). Supportive therapies for schizophrenia: Possible mechanisms and implications for adjunctive psychosocial treatments. Schizophrenia Bulletin, 30, 101–112.PubMedCrossRefGoogle Scholar
  50. Pilling, S., Bebbington, P., Kuipers, E., Garety, P., Geddes, J., Orbach, G., & Morgan, C. (2002). Psychological treatments in schizophrenia: II. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation. Psychological Medicine, 32, 783–791.PubMedGoogle Scholar
  51. Pinto, A., La Pia, S., Mennella, R., Giorgio, D., & DeSimone, L. (1999). Cognitive behavioral therapy and clozapine for clients with treatment-refractory schizophrenia. Psychiatric Services, 50, 901–904.PubMedGoogle Scholar
  52. Remschmidt, H. (2002). Early-onset schizophrenia as a progressive-deteriorating developmental disorder: Evidence from child psychiatry. Journal of Neural Transmission, 109, 101–117.PubMedCrossRefGoogle Scholar
  53. Remschmidt, H., & Theisen, F.M. (2005). Schizophrenia and related disorders in children and adolescents. Journal of Neural Transmission, 69, 121–141.PubMedGoogle Scholar
  54. Ross, R.G., Novins, D., Farley, G.K., & Adler, L.E. (2003). A 1-Year open-label trial of olanzapine in school-age children with schizophrenia. Journal of Child and Adolescent Psychopharmacology, 13, 301–309.PubMedCrossRefGoogle Scholar
  55. Schaeffer, J.L., & Ross, R.G. (2002). Childhood-onset schizophrenia: Premorbid and prodromal diagnostic and treatment histories. Journal of American Academy of Child and Adolescent Psychiatry, 41, 538–545.CrossRefGoogle Scholar
  56. Shen, W.W. (1999). A history of antipsychotic drug development. Comprehensive Psychiatry, 40, 407–414.PubMedCrossRefGoogle Scholar
  57. Shin, L., Bregman, H., Frazier, J., & Noyes, N. (2008). An overview of obesity in children with psychiatric disorders taking atypical antipsychotics. Harvard Review of Psychiatry, 16, 69–79.PubMedCrossRefGoogle Scholar
  58. Sikich, L. (2005). Individual psychotherapy and school interventions for psychotic youth. In R.L. Findling & S.C. Schulz (Eds.), Juvenile-Onset Schizophrenia: Assessment, Neurobiology, and Treatment. (pp. 257–287).Baltimore, MD: John Hopkins Press.Google Scholar
  59. Sikich, L., Frazier, J.A., McClellan, J., Findling, R.L., Vitiello, B., Ritz, L., & Lieberman, J.A. (2008). Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizoaffective disorder: Findings from the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. American Journal of Psychiatry, 165, 1420–1431.PubMedCrossRefGoogle Scholar
  60. Taub, J. & Pearrow, M. (2007). School functioning for children enrolled in community based wraparound services. In C. Newman, C.J. Liberton, K. Kutash & R. Friedman, (Eds.), The 19th Annual Research Conference Proceedings: A System of Care for Children’s Mental Health: Expanding the Research Base (pp. 323–326). Tampa: University of South Florida, Louis de la Parte Florida Mental Health Institute, Research and Training Center for Children’s Mental Health.Google Scholar
  61. Tomoras, V., Mavreas, V., Economou, M., Ioannovich, E., Karydi, V., & Siefanis, C. (2000). The effect of family intervention on chronic schizophrenics under individual psychosocial treatment: A 3-year study. Social Psychiatry and Psychiatric Epidemiology, 35, 487–493.CrossRefGoogle Scholar
  62. Walker, J.S. (2008). How, and why, does wraparound work: A theory of change. In E. J. Bruns & J.S. Walker (Eds.), The resource guide to wraparound. Portland, OR: National Wraparound Initiative, Research and Training Center for Family Support and Children’s Mental Health.Google Scholar
  63. Watson, A.C., Otey, E., Westbrook, A.L., Gardner, A.L., Lamb, T.A., Corrigan, P.W., & Fenton, W.S. (2004). Changing middle schoolers’ attitudes about mental illness through education. Schizophrenia Bulletin, 30, 563–572.PubMedCrossRefGoogle Scholar
  64. Wiersma, D., Nienhuis, F.J., & Stooff, C.J. (1998). Natural course of schizophrenia disorders: A 15-year follow-up of a Dutch incidence cohort. Schizophrenia Bulletin, 24, 75–85.PubMedCrossRefGoogle Scholar
  65. Wilens, T.E. (2009). Straight talk about psychiatric medications for kids (3rd ed.). New York: Guilford Press.Google Scholar
  66. Worthington, J., Hernandez, M., Friedman, B., & Uzzell, D. (2001). Systems of Care: Promising Practices in Children’s Mental Health, 2001 Series, Volume II. Washington, D.C.: Center for Effective Collaboration and Practice, American Institutes for Research.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Huijun Li
    • 1
  • Melissa Pearrow
    • 2
  • Shane R. Jimerson
    • 3
  1. 1.Department of Public PsychiatryCommonwealth Research Center Harvard Medical School Beth Israel Deaconess Medical CenterBostonUSA
  2. 2.Department of Counseling and School PsychologyUniversity of MassachusettsBostonUSA
  3. 3.Gevirtz Graduate School of Education Department of Counseling, Clinical, and School PsychologyUniversity of CaliforniaSanta BarbaraUSA

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