Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability

  • Daisuke Ito
  • Tomohiro Matsumoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 676)


For equal segregation, chromosomes, which are distributed randomly in the nucleus of interphase, must be aligned at the spindle equator in mitosis before the onset of sister chromatid separation. The spindle checkpoint is a surveillance mechanism that delays the onset of sister chromatid separation while each chromosome is on the way to the spindle equator. Failure in the function of the checkpoint results in aneuploidy/polyploidy, which would be a cause of cancer. Here, we review chromosome dynamics in mitosis, molecular mechanisms of the spindle checkpoint and finally tumorigenesis triggered by missegregation of chromosomes.


Sister Chromatid Metaphase Plate Spindle Assembly Checkpoint Spindle Checkpoint Spindle Pole Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Radiation Biology Center and Graduate School of BiostudiesKyoto UniversityKyotoJapan

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