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Nano-scale Force Spectroscopy Applied to Biological Samples

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Nano-Bio-Sensing

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Abstract

This chapter covers the field of AFM-based force spectroscopy (FS) as applied to biological samples ranging from single molecules up to cells. After a brief introduction to atomic force microscopy and to the basic physical phenomena that are involved in FS measurements, we describe some FS experiments that have been conducted using biological systems of increasing complexities. Several experiments describing FS analysis of DNA, proteins, polysaccharides, and whole cells are successively presented.

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Authors and Affiliations

  1. Laboratoire de Physique de la Matière Vivante, EPFL, CH-1015, Lausanne, Switzerland

    Sandor Kasas, Charles Roduit & Giovanni Dietler

Authors
  1. Sandor Kasas
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  2. Charles Roduit
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  3. Giovanni Dietler
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Corresponding author

Correspondence to Sandor Kasas .

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Editors and Affiliations

  1. Fac. Informatique et Communications, Labo. Systèmes Intégrés (LSI), EPFL, Lausanne, 1015, Switzerland

    Sandro Carrara

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Kasas, S., Roduit, C., Dietler, G. (2011). Nano-scale Force Spectroscopy Applied to Biological Samples. In: Carrara, S. (eds) Nano-Bio-Sensing. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6169-3_2

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  • DOI: https://doi.org/10.1007/978-1-4419-6169-3_2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-6168-6

  • Online ISBN: 978-1-4419-6169-3

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