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Nano-scale Force Spectroscopy Applied to Biological Samples

  • Sandor Kasas
  • Charles Roduit
  • Giovanni Dietler
Chapter

Abstract

This chapter covers the field of AFM-based force spectroscopy (FS) as applied to biological samples ranging from single molecules up to cells. After a brief introduction to atomic force microscopy and to the basic physical phenomena that are involved in FS measurements, we describe some FS experiments that have been conducted using biological systems of increasing complexities. Several experiments describing FS analysis of DNA, proteins, polysaccharides, and whole cells are successively presented.

Keywords

Atomic Force Microscope Contour Length Snare Complex Force Spectroscopy Entropic Force 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sandor Kasas
    • 1
  • Charles Roduit
    • 1
  • Giovanni Dietler
    • 1
  1. 1.Laboratoire de Physique de la Matière VivanteEPFLLausanneSwitzerland

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