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Interleukin-24 Gene Therapy for Melanoma

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Gene-Based Therapies for Cancer

Part of the book series: Current Cancer Research ((CUCR))

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Abstract

The interleukin (IL) -24 protein encoded by melanoma differentiation associated-7 (mda-7) gene is a novel IL-10 family cytokine with unique tumor-specific apoptotic and anti-angiogenic properties. Additional role(s) for IL-24, including the regulation of skin inflammation, as suggested by recent data, provide a teleologic role for this melanocyte- and monocyte-produced molecule. Previous studies by our group led to a Phase I trial for local adenoviral therapy delivery in advanced solid tumor patients. These clinical studies employed gene therapy with adenoviral vector–mediated delivery of mda-7/IL-24 (Ad-mda-7/IL-24) and clearly demonstrated a bystander apoptotic effect resulting from IL-24 protein production in injected tumor lesion. While these studies are useful for “proof of principle” for IL-24, we now realize that we must devise means to use this same product, IL-24, systemically to achieve therapeutic success in patients with melanoma. Therefore, gene therapy with a nanoparticle delivery vehicle is now being pursued. We propose that MDA7/IL-24 is a major skin-derived tumor suppressor/cytokine that has profound significance as a biotherapeutic for melanoma and possibly other cancers.

Professor, Department of Experimental Therapeutics; Francis King Black Memorial Professor of Cancer Research; Deputy Head for Research Affairs, Division of Cancer Medicine; and Co-Director, Melanoma Research Program; The University of Texas MD Anderson Cancer Center

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  1. Houston, TX, 77030, USA

    Elizabeth A. Grimm (Professor)

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  1. Nancy Poindexter
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  2. Rajagopal Ramesh
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  3. Suhendan Ekmekcioglu
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  4. Julie Ellerhorst
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  5. Kevin Kim
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  6. Elizabeth A. Grimm
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Correspondence to Elizabeth A. Grimm .

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  1. M.D.Anderson Cancer Center, Dept. Thoracic & Cardiovascular Surgery, University of Texas, Holcombe Blvd. 1515, Houston, 77030, USA

    Jack A. Roth

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Poindexter, N., Ramesh, R., Ekmekcioglu, S., Ellerhorst, J., Kim, K., Grimm, E.A. (2010). Interleukin-24 Gene Therapy for Melanoma. In: Roth, J. (eds) Gene-Based Therapies for Cancer. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6102-0_11

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  • DOI: https://doi.org/10.1007/978-1-4419-6102-0_11

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-6101-3

  • Online ISBN: 978-1-4419-6102-0

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