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Gene-Based Therapies for Cancer pp 155–179Cite as

Lentiviruses: Vectors for Cancer Gene Therapy

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

Lentivirus are the most efficient viral gene transfer vectors. Partitioned engineered backbones containing the essential proteins needed for reverse transcription and integration and separate elements for the transgene payload provide a 3 or 4 safety designed components that when transduced into transient producer cells yield high titre vectors. Applications of these vector systems have been designed for application for suicide gene therapy using thymidine kinase, immunotherapy and vaccine development, gene replacement and gene silencing including RNAi, anti-angiogenesis, an myelosuppression protection studies are discussed. Most of these efforts have moved from basic concept through preclinical testing and many are in early phase clinical trials. Lentiviral backbones remain a very promising approach to safe and stable gene transfer.

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  1. Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Ireland Cancer Center, University Hospitals Case Medical Center and Case Western Reserve University, Wearn 151, 11100 Euclid Avenue, Cleveland, OH, 44106, USA

    Stanton L. Gerson

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  1. Yuan Lin
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  2. Amar Desai
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  3. Stanton L. Gerson
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Correspondence to Stanton L. Gerson .

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    Jack A. Roth

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Lin, Y., Desai, A., Gerson, S.L. (2010). Lentiviruses: Vectors for Cancer Gene Therapy. In: Roth, J. (eds) Gene-Based Therapies for Cancer. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6102-0_10

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