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The Relation of Biofilms to Chronic Otitis Media and Other Ear-Related Chronic Infections

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Abstract

Ear, nose and throat infections (rhinitis, rhinosinusitis, otitis media, adenoiditis and tonsillitis), also termed, upper respiratory tract infections (URTI) are extremely frequent diseases worldwide, especially in childhood. The diseases are caused by viruses or bacteria and occur in both acute and chronic forms.

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References

  • Al-Mazrou KA, Al-Khattaf AS (2008) Adherent biofilms in adenotonsillar diseases in children. Arch Otolaryngol Head Neck Surg 134(1):20–23

    Article  PubMed  Google Scholar 

  • Antonelli PJ, Lee JC, Burne RA (2004) Bacterial biofilms may contribute to persistent cochlear implant infection. Otol Neurotol 25(6):953–957

    Article  PubMed  Google Scholar 

  • Aul JJ, Anderson KW, Wadowsky RM et al (1998) Comparative evaluation of culture and PCR for the detection and determination of persistence of bacterial strains and DNAs in the Chinchilla laniger model of otitis media. Ann Otol Rhinol Laryngol 107(6):508–513

    CAS  PubMed  Google Scholar 

  • Bakaletz LO (2007) Bacterial biofilms in otitis media evidence and relevance. Ped Infect Dis J 26:S17–S19

    Article  Google Scholar 

  • Bendouah Z, Barbeau J, Hamad WA et al (2006) Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with unfavourable evolution after surgery for chronic sinusitis and nasal polyposis. Otolaryngol Head Neck Surg 134:991–996

    Article  PubMed  Google Scholar 

  • Berry JA, Biedlingmaier JF, Whelan PJ (2000) In vitro resistance to bacterial biofilm formation on coated fluoroplastic tympanostomy tubes. Otolaryngol Head Neck Surg 123(3):246–251

    Article  CAS  PubMed  Google Scholar 

  • Biedlingmaier JF, Samaranayake R, Whelan P (1998) Resistance to biofilm formation on otologic implant materials. Otolaryngol Head Neck Surg 118(4):444–451

    Article  CAS  PubMed  Google Scholar 

  • Bothwell MR, Smith AL, Phillips T (2003) Recalcitrant otorrhea due to Pseudomonas biofilm. Otolaryngol Head Neck Surg 129:599–601

    Article  PubMed  Google Scholar 

  • Chole RA, Faddis BT (2002) Evidence for microbial biofilms in cholesteatomas. Arch Otolaryngol Head Neck Surg 128:1129–1133

    PubMed  Google Scholar 

  • Chole RA, Faddis BT (2003) Anatomical evidence of microbial biofilms in tonsillar tissues: a possible mechanism to explain chronicity. Arch Otolaryngol Head Neck Surg 129:634–636

    Article  PubMed  Google Scholar 

  • Cryer J, Schipor I, Perloff JR et al (2004) Evidence of bacterial biofilms in human chronic sinusitis. ORL J Otorhinolaryngol Relat Spec 66:155–158

    PubMed  Google Scholar 

  • Dingman JR, Rayner MG, Mishra S et al (1998) Correlation between presence of viable bacteria and presence of endotoxin in middle-ear effusions. J Clin Microbiol 36(11):3417–3419

    CAS  PubMed  Google Scholar 

  • Dohar JE, Hebda PA, Veeh R et al (2005) Mucosal biofilm formation on middle-ear mucosa in a nonhuman primate model of chronic suppurative otitis media. Laryngoscope 115:1469–1472

    Article  PubMed  Google Scholar 

  • Ehrlich GD, Veeh R, Wang X et al (2002) Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. JAMA 287(13):1710–1715

    Article  PubMed  Google Scholar 

  • Emery BE, Dixit R, Formby CC et al (2003) The resistance of maxillofacial reconstruction plates to biofilm formation in vitro. Laryngoscope 113(11):1977–1982

    Article  CAS  PubMed  Google Scholar 

  • Everaert EP, Mahieu HF, van de Belt-Gritter B et al (1999) Biofilm formation in vivo on perfluoro-alkylsiloxane-modified voice prostheses. Arch Otolaryngol Head Neck Surg 125(12):1329–1332

    CAS  PubMed  Google Scholar 

  • Galli J, Ardito F, Calo L et al (2007) Recurrent upper airway infections and bacterial biofilms. J Laryngol Otol 121:341–344

    Article  CAS  PubMed  Google Scholar 

  • Giebink GS (1989) The microbiology of otitis media. Pediatr Infect Dis J 8(1 Suppl):S18–20

    Google Scholar 

  • Hall-Stoodley L, Hu FZ, Gieseke A et al (2006) Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA 296:202–211

    Article  CAS  PubMed  Google Scholar 

  • Homøe P, Bjarnsholt T, Wessman M et al (2009) Morphological evidence of biofilm formation in Greenlanders with chronic suppurative otitis media. Eur Arch Otorhinolaryngol 266(10):1533–1538

    Article  PubMed  Google Scholar 

  • Kania RE, Lamers GE, Vonk MJ et al (2007) Demonstration of bacterial cells and glycocalyx in biofilms on human tonsils. Arch Otolaryngol Head Neck Surg 133(2):115–121

    Article  PubMed  Google Scholar 

  • Kirketerp-Møller K, Jensen PØ, Fazli M et al (2008) Distribution, organisation and ecology of bacteria in chronic wounds. J Clin Microbiol 46:2717–2722

    Article  PubMed  Google Scholar 

  • Leunisse C, van Weissenbruch R, Busscher HJ et al (2001) Biofilm formation and design features of indwelling silicone rubber tracheoesophageal voice prostheses—an electron microscopical study. J Biomed Mater Res 58(5):556–563

    Article  CAS  PubMed  Google Scholar 

  • Li Z, Kosorok MR, Farrell PM et al (2005) Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis. JAMA 293:581–588

    Article  CAS  PubMed  Google Scholar 

  • Moriyama S, Hotomi M, Shimada J et al (2009) Formation of biofilm by Haemophilus influenzae isolated from pediatric intractable otitis media. Auris Nasus Larynx 161(2):162–170

    Google Scholar 

  • Nason R, Chole RA (2007). Bacterial biofilms may explain chronicity in osteoradionecrosis of the temporal bone. Otol Neurotol 28:1026–1028

    Article  PubMed  Google Scholar 

  • Pawlowski KS, Wawro D, Roland PS (2005) Bacterial biofilm formation on a human cochlear implant. Otol Neurotol 26:972–975

    Article  PubMed  Google Scholar 

  • Pinar E, Öncel S, Karagöz Ü et al (2008) Demonstration of bacterial biofilms in chronic otitis media. Mediterr J Otol;4:64–68

    Google Scholar 

  • Post JC (2001) Direct evidence of bacterial biofilms in otitis media. Laryngoscope 111:2083–2094

    Article  CAS  PubMed  Google Scholar 

  • Post JC, Aul JJ, White GJ et al (1996) PCR-based detection of bacterial DNA after antimicrobial treatment is indicative of persistent, viable bacteria in the chinchilla model of otitis media. Am J Otolaryngol 17(2):106–111

    Article  CAS  PubMed  Google Scholar 

  • Post JC, Preston RA, Aul JJ et al (1995) Molecular analysis of bacterial pathogens in otitis media with effusion. JAMA 273(20):1598–1604

    Article  CAS  PubMed  Google Scholar 

  • Rayner MG, Zhang Y, Gorry MC et al (1998) Evidence of bacterial metabolic activity in culture-negative otitis media with effusion. JAMA 279:296–299

    Article  CAS  PubMed  Google Scholar 

  • Rovers MM, Schilder AGM, Zielhuis GA et al (2004) Otitis media. Lancet 363:465–473

    Article  PubMed  Google Scholar 

  • Saidi IS, Biedlingmaier JF, Whelan P (1999) In vivo resistance to bacterial biofilm formation on tympanostomy tubes as a function of tube material. Otolaryngol Head Neck Surg 120:621–627

    Article  CAS  PubMed  Google Scholar 

  • Store G, Olsen I (2005) Scanning and transmission electron microscopy demonstrates bacteria in osteoradionecrosis. Int J Oral Maxillofac Surg 34:777–781

    Article  CAS  PubMed  Google Scholar 

  • Ueyama T, Kurono Y, Shirabe K et al (1995) High incidence of Haemophilus influenzae in nasopharyngeal secretions and middle ear effusions as detected by PCR. J Clin Microbiol 33(7):1835–1838

    CAS  PubMed  Google Scholar 

  • Verhoeff M, van der Veen EL, Rovers MM et al (2006) Chronic suppurative otitis media: a review. Int J Pediatr Otorhinolaryngol 70:1–12

    Article  PubMed  Google Scholar 

  • Wang EW, Agostini G, Olomu O et al (2008) Gentian violet and ferric ammonium citrate disrupt Pseudomonas aeruginosa biofilms. Laryngoscope 118(11):2050–2056

    Article  PubMed  Google Scholar 

  • Wang EW, Jung JY, Pashia ME et al (2005) Otopathogenic Pseudomonas aeruginosa strains as competent biofilm formers. Arch Otolaryngol Head Neck Surg 131(11):983–989

    Article  PubMed  Google Scholar 

  • Zuliani G, Carron M, Gurrola J et al (2006) Identification of adenoid biofilms in chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol 70(9):1613–1617

    Article  PubMed  Google Scholar 

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Correspondence to Preben Homøe .

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Homøe, P., Johansen, H.K. (2011). The Relation of Biofilms to Chronic Otitis Media and Other Ear-Related Chronic Infections. In: Bjarnsholt, T., Jensen, P., Moser, C., Høiby, N. (eds) Biofilm Infections. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6084-9_3

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