Risk Lesions of the Breast: Usual Ductal Hyperplasia, Atypical Ductal Hyperplasia, Lobular Neoplasia, and the Spectrum of Columnar Cell Alterations

  • Reetesh Pai
  • Gerald J. Berry


Classifying breast lesions into diagnostically useful categories is complicated by the gradual continuum of cytologic and architectural microscopic changes seen in proliferative breast lesions. This morphologic continuum does not easily allow for distinct boundaries between these diagnostic entities. Pathologists have attempted to subclassify proliferative breast lesions into diagnostically useful groups for the purpose of providing an assessment of the risk of developing invasive carcinoma in the future to the patient. The relative risk of various lesions is provided. These lesions represent histologic markers of increased risk to the patient and should be distinguished from precursor lesions which are suspected or known to be lesions capable of directly progressing to invasive carcinoma. To ensure interobserver reproducibility within these diagnostic groups, a uniform application of the histologic criteria defined for each of these categories is essential. In this chapter, we will discuss the diagnostic criteria commonly employed for the various risk lesions routinely seen in practice.


Core Needle Biopsy Atypical Ductal Hyperplasia Radial Scar Flat Epithelial Atypia Lobular Neoplasia 
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Copyright information

© Springer New York 2010

Authors and Affiliations

  1. 1.Department of PathologyStanford University School of MedicineStanfordUSA

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