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Cancer Genetics pp 33–63Cite as

Hereditary Diffuse Gastric Cancer

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 155))

Abstract

Gastric cancer is one of the world’s leading causes of cancer mortality. A small percentage of cases can be attributed to heritable mutations in highly penetrant cancer susceptibility genes. In this chapter we will focus on the genetic cause of hereditary diffuse gastric cancer (HDGC). Until 10 years ago, individuals from these families lived with the uncertainty of developing lethal gastric cancer. Today, HDGC families can be identified, tested for causative mutations in CDH1, and for those families where a pathogenic mutation can be identified, prophylactic total gastrectomy can be implemented in asymptomatic mutation carriers who elect to virtually eliminate their risk of developing this lethal disease.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine and Department of Medical Genetics, University of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada, V5Z 4E6

    Kasmintan Schrader

  2. Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada, V5Z 4E6

    David Huntsman

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  1. Kasmintan Schrader
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Correspondence to Kasmintan Schrader .

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  1. The UAB Comprehensive Cancer Center, Division of Hematology/Oncology, The University of Alabama at Birmingham, Birmingham, 35294-3300, Alabama, USA

    Boris Pasche

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Schrader, K., Huntsman, D. (2010). Hereditary Diffuse Gastric Cancer. In: Pasche, B. (eds) Cancer Genetics. Cancer Treatment and Research, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6033-7_3

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