Cancer Niche

  • Shi-Ming Tu
Part of the Cancer Treatment and Research book series (CTAR, volume 154)


Malignant transformation is not an entirely “cell-centric” event. It also involves disrupted homeostasis between a perturbed cell and its disturbed niche.


Stem Cell Cancer Stem Cell Malignant Epithelial Cell Stromal Interaction Progenitor Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Schofield R (1978) The relationship between the spleen colony-forming cell and the hematopoietic stem cell. Blood Cells 4:7–25PubMedGoogle Scholar
  2. 2.
    Kai T, Spradling A (2003) An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells. Proc Natl Acad Sci USA 100:4633–4638CrossRefPubMedGoogle Scholar
  3. 3.
    Stevens LC (1964) Experimental production of testicular teratomas in mice. Proc Natl Acad Sci USA 52:654–661CrossRefPubMedGoogle Scholar
  4. 4.
    Mintz B, Illmensee K (1975) Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 72:3585–3589CrossRefPubMedGoogle Scholar
  5. 5.
    Dolberg DS, Bissell MJ (1984) Inability of Rous sarcoma virus to cause sarcomas in avian embryo. Nature 309:552–556CrossRefPubMedGoogle Scholar
  6. 6.
    Gershenson M, Graves K, Carson SD, Wells RS, Pierce GB (1986) Regulation of melanoma by the embryonic skin. Proc Natl Acad Sci USA 83:7307–7310CrossRefGoogle Scholar
  7. 7.
    Topczewska JM, Postovit L-M, Margaryan NV et al (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12:925–932CrossRefPubMedGoogle Scholar
  8. 8.
    Postovit LM, Seftor EA, Seftor REB, Hendrix MJC (2006) A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells 24:501–505CrossRefPubMedGoogle Scholar
  9. 9.
    Fialkow PJ, Thomas ED, Bryant JI, Neiman PE (1971) Leukaemic transformation of engrafted human marrow cells in vivo. Lancet 1:251–255CrossRefPubMedGoogle Scholar
  10. 10.
    Flynn CM, Kauffman DS (2007) Donor cell leukemia: insights into cancer stem cells and the stem cell niche. Blood 109:2688–2692PubMedGoogle Scholar
  11. 11.
    Hertenstein B, Hambach L, Bacigalupo A et al; Complications Subcommittee of the Chronic Leukaemia Working Party of the EBMT (2005) Development of leukemia in donor cells after allogeneic stem cells transplantation – a survey of the European Group for Blood and Marrow Transplantation (EBMT). Hematologica 90:969–975Google Scholar
  12. 12.
    Stoler DL, Chen N, Basik M et al (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci USA 96:15121–15126CrossRefPubMedGoogle Scholar
  13. 13.
    Barcellos-Hoff MH, Ravani SA (2000) Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res 60:1254–1260PubMedGoogle Scholar
  14. 14.
    Bhowmick NA, Chytil A, Plieth D et al (2004) TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303:848–851CrossRefPubMedGoogle Scholar
  15. 15.
    Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS (1996) Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274:2057–2059CrossRefPubMedGoogle Scholar
  16. 16.
    Grum-Schwensen B, Klingelhofer J, Berg CH et al (2005) Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene. Cancer Res 65:3772–3780CrossRefPubMedGoogle Scholar
  17. 17.
    Orimo A, Gupta PB, Sgroi DC et al (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335–348CrossRefPubMedGoogle Scholar
  18. 18.
    Littlepage LE, Egeblad M, Werb Z (2005) Coevolution of cancer and stromal cellular responses. Cancer Cell 7:499–500CrossRefPubMedGoogle Scholar
  19. 19.
    Kaplan RN, Riba RD, Zacharoulis S et al (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820–827CrossRefPubMedGoogle Scholar
  20. 20.
    McAllister SS, Gifford AM, Greiner AL et al (2008) Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 133:994–1005CrossRefPubMedGoogle Scholar
  21. 21.
    Tu S-M, Lin S-H (2008) Current trials using bone-targeting agents in prostate cancer [review]. Cancer J 14(1):35–39, Erratum in Cancer J 2008;14(3):199CrossRefPubMedGoogle Scholar
  22. 22.
    Covello KL, Kehler J, Yu H et al (2006) HIF-2a regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev 20:557–570CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.The University of Texas M. D. Anderson Cancer CenterHoustonUSA

Personalised recommendations