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Factors Impacting the Tumor Localization and Distribution of Antibody-Based Therapeutics in Oncology

  • David C. Blakey
Chapter

Abstract

Distribution of antibody-based therapeutics from the vascular space to the target tumor compartment is an important consideration in designing antibody-based oncology drugs. Mouse tumor models represent a reasonable approach for exploring antibody biodistribution. In general, a number of factors such as molecular size, antibody dose, and the length of in vivo tumor exposure can influence antibody localization and tumor penetration. With a few exceptions, the current available data indicate that at clinically relevant doses (ranging from 1 to 10 mg/kg) and over a reasonable clinical exposure time (days rather than hours), antibody biodistribution into tumors is unlikely to be the most significant factor hindering the clinical efficacy of antibody-based therapeutics. Other factors such as antigenic heterogeneity leading to variable distribution of antibody drugs into the tumor, or intrinsic resistance to antibody-mediated effects, may play a far greater role in the resistance properties impacting the antibody efficacy profiles.

Keywords

Target Antigen Human Tumor Xenograft Tumor Penetration Tumor Compartment Intact Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Oncology DiscoveryAstraZenecaMacclesfield, CheshireUnited Kingdom

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