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Discovery Process for Antibody-Based Therapeutics

  • Heather H. Shih
Chapter

Abstract

Antibody-based therapeutics have entered the center stage of drug discovery as a result of a major shift in focus of many pharmaceutical companies from small molecules to a broader portfolio containing both protein and chemical therapeutic agents. The field is benefiting from both an increased understanding of the mechanistic basis of antibody-derived therapeutics and the development of sophisticated technologies to derive safe and targeted biotherapeutics. This chapter provides a general overview of the discovery process relevant for generation of antibody-based therapeutics. The discussion elaborates on target selection and validation, screening preparation, lead identification and optimization, as well as clinical candidate selection. In addition, an overview of immunogenicity, a unique challenge for protein-based therapeutics, is provided. A case study is also included to illustrate the discovery process for bapineuzumab, a humanized anti-amyloid beta (Aβ) monoclonal antibody, currently in Phase III clinical trials for the treatment of Alzheimer’s disease.

Keywords

Therapeutic Antibody Drug Discovery Process Lead Molecule Therapeutic Candidate Clinical Candidate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.External Research SolutionsPfizerCambridgeUSA

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