Application of Population Pharmacokinetic-Pharmacodynamic Approaches in the Design of Translational Strategies for Development of Antibody-Based Therapeutics



Population-based pharmacokinetic-pharmacodynamic (PK-PD) approaches have been successfully applied in various stages of drug development over the last few decades. The development of antibody-based therapeutics has benefited substantially from the utilization of population approaches. Moreover, almost all FDA-approved monoclonal antibody therapeutics have been evaluated using population approaches. In this chapter, application of population PK-PD methods will be reviewed in the context of translational strategies employed during the development of antibody-based therapeutics.


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.PK/PD and in vivo PharmacologyMerck Research Laboratory—Palo AltoPalo AltoUSA

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