Follicular Lesions

  • Douglas P. Clark
  • William C. Faquin
Part of the Essentials in Cytopathology book series (EICP, volume 8)


Follicular carcinoma (FC) is the second most common malignancy of the thyroid after papillary thyroid carcinoma (PTC), representing approximately 15% of all thyroid carcinomas. Most FCs are minimally invasive and are categorized as well-differentiated tumors that have an excellent prognosis. A small subset of FCs, however, are widely invasive carcinomas (i.e., grossly recognizable as carcinomas) with a much more aggressive clinical course. In addition, the classic subtype of poorly differentiated thyroid carcinoma is insular carcinoma, a rare, aggressive follicular-derived tumor.


Papillary Thyroid Carcinoma Fine Needle Aspiration Thyroid Nodule Grave Disease Parathyroid Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Reading

  1. Bongiovanni M, Bloom L, Krane JF, Baloch Z, Powers CN, Hintermann S, Pache JC, Faquin WC. Cytomorphologic features of poorly differentiated thyroid carcinoma: a multi-institutional analysis of 40 cases. Cancer Cytopathol 2009;117:185–194.CrossRefGoogle Scholar
  2. Brennan MD, Bergstrahal EJ, van Heerden JA, McConahay WM. Follicular thyroid cancer treated at the Mayo Clinic, 1946–1970: initial manifestations, pathological findings, therapy and outcome. Mayo Clin Proc 1991;66:11.CrossRefGoogle Scholar
  3. D’Avanzo A, Treseler P, Ituarte PHG, et al. Follicular thyroid carcinoma: histology and prognosis. Cancer (Phila) 2004;100:1123–1129.CrossRefGoogle Scholar
  4. Faquin WC, Powers CN. Aggressive forms of follicular-derived thyroid carcinoma. Pathol Case Rev 2003;8:25–33.CrossRefGoogle Scholar
  5. French CA, Alexander EK, Cibas ES, et al. Genetic and biological subgroups of low-stage follicular thyroid cancer. Am J Pathol 2003;162:1053–1060.PubMedCrossRefGoogle Scholar
  6. Gharib J, Goellner JR. Fine-needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med 1993;118:282–289.PubMedGoogle Scholar
  7. Greaves TS, Olvera M, Florentine BD, et al. Follicular lesions of thyroid: a 5-year fine-needle aspiration experience. Cancer Cytopathol 2000;90:335–341.Google Scholar
  8. Liu F, Gnepp DR, Pisharodi LR. Fine needle aspiration of parathyroid lesions. Acta Cytol 2004;48:133–136.PubMedCrossRefGoogle Scholar
  9. Segev DL, Clark DP, Zeiger MA, Umbricht C. Beyond the suspicious thyroid fine needle aspirate. Acta Cytol 2003;47:709–722.PubMedCrossRefGoogle Scholar
  10. Shaha A, Loree TR, Shah JP. Prognostic factors and risk group analysis in follicular carcinoma of the thyroid. Surgery (St. Louis) 1995;118:1131.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Department of Pathology Harvard Medical SchoolMassachusetts General HospitalBostonUSA

Personalised recommendations