Approach to Thyroid FNA Cytopathology: An Overview

Part of the Essentials in Cytopathology book series (EICP, volume 8)


In this book, we present a practical, algorithmic approach to the diagnosis of thyroid fine needle aspirations (FNAs) (Figure 3.1). This approach uses a combination of low-magnification assessment of cellular components, evaluation of cytoarchitectural patterns, and high-magnification scrutiny of nuclear features. This approach will also enable the placement of FNAs into diagnostic categories that have recently been developed from a National Cancer Institute (NCI) conference on thyroid FNA termed the Bethesda System for Reporting Thyroid Cytopathology (BSRTC).

Suggested Reading

  1. De los Santos ET, Keyhani-Rofagha S, Cunningham JJ, Mazzaferri EL. Cystic thyroid nodules. The dilemma of malignant lesions. Arch Intern Med 1990;150(7):1422–1427.PubMedCrossRefGoogle Scholar
  2. Gharib H, Goellner JR. Fine-needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med 1993;118(4):282–289.PubMedGoogle Scholar
  3. Goellner JR, Gharib H, Grant CS, Johnson DA. Fine needle aspiration cytology of the thyroid, 1980 to 1986. Acta Cytol 1987;31(5):587–590.PubMedGoogle Scholar
  4. Hedinger CE. Histological typing of thyroid tumours. In: Hedinger CE (ed) International histological classification of tumours, vol II. Berlin: Springer, 1988.Google Scholar
  5. LiVolsi VA. Surgical pathology of the thyroid. Major problems in pathology, vol 22. Baltimore: Saunders, 1990.Google Scholar
  6. Mazzaferri EL. An overview of the management of papillary and follicular thyroid carcinoma. Thyroid 1999;9(5):421–427.PubMedCrossRefGoogle Scholar
  7. Rosai J, Carcangiu ML, Delellis RA. Tumors of the thyroid gland. In: Rosai J (ed) Atlas of tumor pathology. American Registry of Pathology, Third Series, Fascicle 5. Washington, DC: Armed Forces Institute of Pathology, 1992.Google Scholar
  8. Suen KC, et al. Guidelines of the Papanicolaou Society of Cytopathology for the examination of fine-needle aspiration specimens from thyroid nodules. Mod Pathol 1996;9(6):710–715.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Department of Pathology Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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