How to Perform and Process a Thyroid FNA

  • Douglas P. Clark
  • William C. Faquin
Part of the Essentials in Cytopathology book series (EICP, volume 8)


Thyroid fine needle aspirations (FNAs) are among the most challenging FNAs to perform because of the anatomic location and the vascularity of the thyroid gland. However, this challenge must be mastered because accurate diagnosis is dependent on a high-quality, well-prepared specimen.


Thyroid Gland Papillary Thyroid Carcinoma Thyroid Nodule Hank Balance Salt Solution Direct Smear 
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Suggested Reading

  1. AACE/AAES medical/surgical guidelines for clinical practice: management of thyroid carcinoma. American Association of Clinical Endocrinologists. American College of Endocrinologists. Endocrinol Pract 2001;7(3):202–220.Google Scholar
  2. Burguera B, Gharib H. Thyroid incidentalomas. Prevalence, diagnosis significance, and management. Endocrinol Metab Clin N Am 2000;29(1):187–203.CrossRefGoogle Scholar
  3. Field S. AACE clinical practice guidelines for the diagnosis and management of thyroid nodules. Endocrinol Pract 1996;2(1):78–84.Google Scholar
  4. NCCLS. Fine needle aspiration biopsy (FNAB) techniques; approved guideline. NCCLS document GP20-A. NCCLS, 940 West Valley Road, Suite 1400, Wayne, PA, 1986.Google Scholar
  5. Tulecke MA, Wang HH. ThinPrep for cytologic evaluation of follicular thyroid lesions: correlation with histologic findings. Diagn Cytopathol 2004;30(1):7–13.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Department of Pathology Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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