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The Cochlear Nucleus: The New Frontier

Chapter
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 35)

Abstract

Paraphrasing Lord Kelvin, “If you can’t make a model, you didn’t understand.” Conceptual models of the neuronal circuitry within the auditory brainstem have been around for a long time. With the advent of supercomputers and the ubiquity of laptops, computational modeling these days is relatively common.

Keywords

Stellate Cell Spike Train Cochlear Nucleus Tone Burst Good Frequency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations and Acronyms

2D

two-dimensional

AM

amplitude-modulated

AN

auditory nerve

AVCN

anteroventral cochlear nucleus

bK, B

sensitivity to potassium conductance

BBN

broad-band noise

BF

best frequency

BW

bandwidth

BWA→B

bandwidth of cell group A sending connections to cell B

c

threshold sensitivity (0–1)

chop-S

chopper-sustained

chop-T

chopper-transient

CA→B

center frequency offset from cell group A to cell B

CN

cochlear nucleus

dB SPL

decibels sound pressure level

DCN

dorsal cochlear nucleus

DSI

depolarization-induced suppression of inhibition

E

neuron transmembrane potential

Eex

excitatory reversal potential

Ein

inhibitory reversal potential

EK, EK

potassium reversal potential

ES

prior soma potential

gAB

conductance of the synaptic connection from cell A to B

gex

normalized excitatory synaptic conductance

gin

normalized inhibitory synaptic conductance

gk

normalized potassium conductance

G

resting conductance

Gex

excitatory synaptic conductance

Gin

inhibitory synaptic conductance

Gk, GK

potassium conductance

HRP

horseradish peroxidase

HRTF

head-related transfer function

Ih

a Ca+-sensitive, hyperpolarization-activated inward rectifier

I–V

current-voltage

I2-cells

inhibitory interneurons with type II unit RMs

ISIH

interspike interval histogram

KLT

low-threshold K+

LTD

long-term depression

LTP

long-term potentiation

NAB

number of cell A connections to cell B

On

Onset

On-C

onset-chopper

On-I

ideal onset

On-L

onset with late activity

P-cells

principal cells

PL

Primarylike

Pri-N

primarylike-with-notch

PS

potential in soma

PSTH

peristimulus time histogram

PVCN

posterioventral cochlear nucleus

R–C

resistance-capacitance

RM

response map

S

spiking variable indicating whether a cell has fired

SA

input spike from cell A

SpAc

spontaneous activity

SC

magnitude of step current injected into a point neuron

SCN

the input current

SR

spontaneous rate

TGK

refractory time constant

TH

neuron threshold

TH0

initial neuron threshold

TMEM

membrane time constant

TTH

time constant for accommodation

VCN

ventral cochlear nucleus

Vm

membrane potential relative to rest

W-cells

wideband inhibitors

θ

spike threshold voltage

σ

conductance step

σAB

the connection strength from cell A to cell B

τ

time constant

τAB

time constant of synaptic connection from cell A to cell B

τK

potassium time constant

τm

membrane time constant

Notes

Acknowledgments

The authors would like to acknowledge the intellectual and programming contributions to the DCN computational model by Drs. K. Davis, K. Hancock and T. McMullen, and the financial support over the years by NIH and Boston University’s Hearing Research Center and Biomedical Engineering department.

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Authors and Affiliations

  1. 1.Department of Biomedical EngineeringBoston UniversityBostonUSA

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