Advertisement

Multi-organ Dysfunction Syndrome

  • Paul Ellis Marik
Chapter

Abstract

With the widespread use of advanced technology for organ support, patients rarely die from their presenting disease but rather from its pathophysiological consequences, namely the sequential dysfunction and failure of several organ systems. This syndrome has been called “multi-system organ failure” (MSOF), “multiple organ system failure” (MOSF), and more recently “multi-organ dysfunction syndrome” (MODS). MODS has an extraordinarily high mortality and, for many patients, the support of this syndrome does not improve survival but rather prolongs the dying process.

Keywords

Organ Failure Circulatory Shock Multiple Organ Dysfunction Score Multiple Organ System Failure Splanchnic Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Society of Critical Care Medicine Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864–874.CrossRefGoogle Scholar
  2. 2.
    Bone RC, Sibbald WJ, Sprung CL. The ACCP-SCCM Consensus Conference on sepsis and organ failure. Chest. 1992;101:1481–1483.PubMedCrossRefGoogle Scholar
  3. 3.
    Tran DD, Groeneveld ABJ, van der Meulen J. Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Crit Care Med. 1990;18:474–479.PubMedCrossRefGoogle Scholar
  4. 4.
    Deitch EA. Multiple organ failure: pathophysiology and potential future therapy. Ann Surg. 1992;216:117–134.PubMedCrossRefGoogle Scholar
  5. 5.
    Deitch EA. Overview of multiple organ failure. In: Prough DS, Traystman RJ, eds. Critical Care: State of the art. Anaheim, CA: Society of Critical Care Medicine; 1993: 131–168.Google Scholar
  6. 6.
    Tilney NL, Bailey GL, Morgan AP. Sequential system failure after rupture of abdominal aortic aneurysms: an unsolved problem in postoperative care. Ann Surg. 1973;178:117–122.PubMedCrossRefGoogle Scholar
  7. 7.
    Smith LH, Post RS, Teschan PE. Post-traumatic renal insufficiency in military casualties. II. Management, use of an artificial kidney, prognosis. In: Howard JM, ed. Battle Casualties in Korea: Studies of the Surgical Research Team. Washington, DC: Government Printing Office; 1974:31–50.Google Scholar
  8. 8.
    Petty TL. Adult respiratory distress syndrome: a historical perspective and definition. Respir Med. 1981;2:99–103.CrossRefGoogle Scholar
  9. 9.
    Eiseman B, Beart R, Norton L. Multiple system organ failure. Surg Gynecol Obstet. 1977;144:323–326.PubMedGoogle Scholar
  10. 10.
    Fry DE. Multiple system organ failure. Surg Clin North Am. 1988;68:107–122.PubMedGoogle Scholar
  11. 11.
    Mizock BA. The multiple organ dysfunction syndrome. Dis Mon. 2009;55:476–526.PubMedCrossRefGoogle Scholar
  12. 12.
    Villar J, Maca-Meyer N, Perez-Mendez L, et al. Bench-to-bedside review: understanding genetic predisposition to sepsis. Crit Care. 2004;8:180–189.PubMedCrossRefGoogle Scholar
  13. 13.
    Cerra FB. Multiple organ failure syndrome. Dis Mon. 1992;38:843–947.PubMedCrossRefGoogle Scholar
  14. 14.
    Carrico CJ, Meakins JL, Marshall JC, et al. Multiple-organ-failure syndrome. Arch Surg. 1986;121:196–208.PubMedCrossRefGoogle Scholar
  15. 15.
    Doig CJ, Sutherland LR, Sandham JS, et al. Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med. 1998;158:444–451.PubMedGoogle Scholar
  16. 16.
    Deitch EA. Multiple organ failure. Adv Surg. 1993;26:333–356.PubMedGoogle Scholar
  17. 17.
    Berrtleff MJOE, Bruining HA. How should multiple organ dysfunction syndrome be assessed? A review of the variations in current scoring systems. Eur J Surg. 1997;163:405–409.Google Scholar
  18. 18.
    Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707–710.PubMedCrossRefGoogle Scholar
  19. 19.
    Marshall JC, Cook DJ, Christou NV, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23:1638–1652.PubMedCrossRefGoogle Scholar
  20. 20.
    Khadaroo RG, Marshall JC. ARDS and the multiple organ dysfunction syndrome. Common mechanisms of a common systemic process. Crit Care Clin. 2002;18:127–141.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineEastern Virginia Medical SchoolNorfolkUSA

Personalised recommendations