Coagulopathy and FFP Transfusions

  • Paul Ellis Marik


Coagulation disorders are commonly encountered in the ICU. Many conditions including sepsis, malignancy, trauma, vasculitic disorders, and obstetrical accidents may give rise to a coagulopathy. In addition, patients may have medical conditions which predispose them to developing a coagulopathy, e.g., patients with liver disease, renal failure, lupus, leukemia, etc. Sepsis, however, is the single most common factor leading to a coagulopathy and DIC. DIC has been reported in about 10–20% of patients with gram-negative bacteremia and 70% of patients with septic shock. In patients with sepsis, DIC appears to be an important independent predictor of ARDS, multiple organ dysfunction syndrome, and death (see Chapter 10).


Disseminate Intravascular Coagulation Multiple Organ Dysfunction Syndrome Coagulation Test Amniotic Fluid Embolism Overt Disseminate Intravascular Coagulation 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineEastern Virginia Medical SchoolNorfolkUSA

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