Stress Ulcer Prophylaxis



In 1969, Skillman and colleagues reported a clinical syndrome of lethal stress ulceration in 7 of 150 (5%) consecutive ICU patients. These patients had in common respiratory failure, hypotension, and sepsis.1 Pathological examination demonstrated multiple superficial ulcers which were confined to the gastric fundus. Following this report, these authors performed a randomized controlled study in which 100 critically ill ICU patients at risk of “stress ulceration” were randomized to either antacid prophylaxis (titrated to keep the gastric pH above 3.5) or no prophylaxis.2 Two of 51 (4%) treated patients had gastrointestinal bleeding (GIB) as compared to 12 of 49 (25%) control patients (p <0.005).


Enteral Nutrition Mucosal Blood Flow Stress Ulcer Prophylaxis Early Enteral Nutrition Jejunostomy Feeding Tube 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineEastern Virginia Medical SchoolNorfolkUSA

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