Takotsubo Cardiomyopathy

  • Paul Ellis Marik


Takotsubo cardiomyopathy also known as apical ballooning syndrome (ABS) is a unique reversible cardiomyopathy that is frequently precipitated by a stressful event and has a clinical presentation that is often indistinguishable from an acute myocardial infarction. This distinct cardiac syndrome was originally described in Japan in 1990 and named after the “octopus trapping pot,” which has a round bottom and a narrow neck, which closely resembles the left ventriculogram during systole in these patients.1 Approximately 90% of all reported cases have been in women. The mean age has ranged from 58 to 75 years, with <3% of the patients being <50 years.2,3 The reason for the female predominance is unknown but raises the question as to whether withdrawal from estrogens contributes to the pathogenesis.


Acute Myocardial Infarction Brain Natriuretic Peptide Takotsubo Cardiomyopathy Plasma Brain Natriuretic Peptide Ventricular Outflow Tract Obstruction 
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  1. 1.
    Kurisu S, Sato H, Kawagoe T, et al. Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J. 2002;143:448–455.PubMedCrossRefGoogle Scholar
  2. 2.
    Regnante RA, Zuzek RW, Weinsier SB, et al. Clinical characteristics and four-year outcomes of patients in the Rhode Island Takotsubo Cardiomyopathy Registry. Am J Cardiol. 2009;103:1015–1019.PubMedCrossRefGoogle Scholar
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    Akashi YJ, Goldstein DS, Barbaro G, et al. Takotsubo cardiomyopathy: a new form of acute, reversible heart failure. Circulation. 2008;118:2754–2762.PubMedCrossRefGoogle Scholar
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    Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J. 2008;155:408–417.PubMedCrossRefGoogle Scholar
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    Yoshioka T, Hashimoto A, Tsuchihashi K, et al. Clinical implications of midventricular obstruction and intravenous propranolol use in transient left ventricular apical ballooning (Tako-tsubo cardiomyopathy). Am Heart J. 2008;155:526–527.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineEastern Virginia Medical SchoolNorfolkUSA

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