Self-assembled Nanogel Engineering

  • Nobuyuki Morimoto
  • Kazunari Akiyoshi


Functional nanogels have been designed by the self-assembly of various associating polymers. In particular, cholesterol-bearing polysaccharides form physically crosslinked nanogels by self-assembly in water. The nanogels trap proteins mainly by hydrophobic interaction and show chaperon-like activity. They are useful as polymeric nanocarriers especially in protein delivery. Macrogels with well-defined nanostructures were obtained by self-assembly and chemical crosslinking of these nanogels as building blocks.


Raft Polymerization PNIPAM Chain Semidilute Solution PNIPAM Hydrogel Spiropyran Molecule 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Materials Processing, Graduate School of EngineeringTohoku UniversitySendaiJapan
  2. 2.Institute of Biomaterials and BioengineeringTokyo Medical and Dental UniversityTokyoJapan

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