Abstract
Hydrogels have been widely applied in biomedical applications, such as drug delivery and tissue engineering, due to their many favorable characteristics. Their high water content renders them compatible with living tissues and proteins and their rubbery nature minimizes damage to the surrounding tissue. Their mechanical properties parallel those of soft tissues, making them particularly appealing for engineering of these tissues. Hydrogels used in tissue engineering are preferably biodegradable, thus further surgery, after the hydrogels has performed its function, is not required. Also, biodegradable hydrogels allow for the replacement of the hydrogels over time by the extracellular matrix produced when cells are incorporated. The biofunctionality of hydrogels is essential to guide cellular behavior such as proliferation, differentiation, and matrix production. An on-demand biofunction can be obtained by the incorporation of growth factors into hydrogels to enhance cellular proliferation in the tissue-engineered matrices.
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References
Langer R, Vacanti JP (1993) Science 260:920–926
Yang S, Leong K-F, Du Z et al (2001) Tissue Eng 7:679–689
Drury JL, Mooney DJ (2003) Biomaterials 24:4337–4351
Wichterle O, Lim D (1960) Nature 185:117–118
Kuo CK, Li W-J, Mauck RL et al (2006) Curr Opin Rheumatol 18:64–73
Kim J, Kim IS, Cho TH et al (2007) Biomaterials 28:1830–1837
Kamath KR, Park K (1993) Adv Drug Deliv Rev 11:59–84
Raeber GP, Lutolf MP, Hubbell JA (2005) Biophys J 89:1374–1388
Bryant SJ, Anseth KS (2002) J Biomed Mater Res 59:63–72
Bryant SJ, Anseth KS (2003) J Biomed Mater Res A 64A:70–79
Martens PJ, Bryant SJ, Anseth KS (2003) Biomacromolecules 4:283–292
Bryant SJ, Durand KL, Anseth KS (2003) J Biomed Mater Res A 67A:1430–1436
Bryant SJ, Bender RJ, Durand KL et al (2004) Biotechnol Bioeng 86:747–755
Lutolf MP, Lauer-Fields JL, Schmoekel HG et al (2003) Proc Natl Acad Sci U S A 100:5413–5418
Burdick JA, Chung C, Jia X et al (2005) Biomacromolecules 6:386–391
Ibusuki S, Halbesma GJ, Randolph MA et al (2007) Tissue Eng 13:1995–2001
Hong Y, Song H, Gong Y et al (2007) Acta Biomater 3:23–31
Lu L, Zhu X, Valenzuela RG et al (2001) Clin Orthop Relat Res 391S:S251–S270
Breuls RGM, Jiya TU, Smit TH (2008) Open Orthop J 2:103–109
Engler AJ, Sen S, Sweeney HL et al (2006) Cell 126:677–689
Chung C, Burdick JA (2008) Adv Drug Deliv Rev 60:243–262
Narine K, Wever OD, Valckenborgh DV et al (2006) Tissue Eng 12:2707–2716
Malafaya PB, Silva GA, Reis RL (2007) Adv Drug Deliv Rev 59:207–233
Nuttelman CR, Mortisen DJ, Henry SM et al (2001) J Biomed Mater Res 57:217–223
Stabenfeldt SE, Garcia AJ, LaPlaca MC (2006) J Biomed Mater Res A 77A:718–725
Ifkovits JL, Burdick JA (2007) Tissue Eng 13:2369–2385
Nguyen KT, West JL (2002) Biomaterials 23:4307–4314
Bryant SJ, Davis-Arehart KA, Luo N et al (2004) Macromolecules 37:6726–6733
Mawad D, Martens PJ, Odell RA et al (2007) Biomaterials 28:947–955
Park YD, Tirelli N, Hubbell JA (2003) Biomaterials 24:893–900
Hong Y, Mao Z, Wang H et al (2006) J Biomed Mater Res A 79A:913–922
Kim SH, Won CY, Chu CC (1999) Carbohydr Polym 40:183–190
Bryant SJ, Nuttelman CR, Anseth KS (2000) J Biomater Sci Polym Ed 11:439–457
Lukaszczyk J, Smiga M, Jaszcz K et al (2005) Macromol Biosci 5:64–69
Hiemstra C, Zhou W, Zhong Z et al (2007) J Am Chem Soc 129:9918–9926
Zhu W, Ding J (2006) J Appl Polym Sci Symp 99:2375–2383
Maia J, Ferreira L, Carvalho R et al (2005) Polymer 46:9604–9614
Lee KY, Alsberg E, Mooney DJ (2001) J Biomed Mater Res 56:228–233
Hennink WE, van Nostrum CF (2002) Adv Drug Deliv Rev 54:13–36
Bulpitt P, Aeschlimann D (1999) J Biomed Mater Res 47:152–169
Balakrishnan B, Jayakrishnan A (2005) Biomaterials 26:3941–3951
Riley CM, Fuegy PW, Firpo MA et al (2006) Biomaterials 27:5935–5943
Zheng Shu X, Liu Y, Palumbo FS et al (2004) Biomaterials 25:1339–1348
Vanderhooft JL, Mann BK, Prestwich GD (2007) Biomacromolecules 8:2883–2889
Hiemstra C, vanderAa LJ, Zhong Z et al (2007) Macromolecules 40:1165–1173
Hiemstra C, VanderAa LJ, Zhong Z et al (2007) Biomacromolecules 8:1548–1556
Tortora M, Cavalieri F, Chiessi E et al (2007) Biomacromolecules 8:209–214
Metters A, Hubbell J (2005) Biomacromolecules 6:290–301
Lutolf MP, Raeber GP, Zisch AH et al (2003) Adv Mater 15:888–892
Park Y, Lutolf MP, Hubbell JA et al (2004) Tissue Eng 10:515–522
Salinas CN, Cole BB, Kasko AM et al (2007) Tissue Eng 13:1025–1034
Cotton GJ, Muir TW (1999) Chem & Biol 6:R247–R256
Wathier M, Jung PJ, Carnahan MA et al (2004) J Am Chem Soc 126:12744–12745
Wathier M, Johnson CS, Kim T et al (2006) Bioconjug Chem 17:873–876
Rostovtsev VV, Green LG, Fokin VV et al (2002) Angew Chem Int Edit 41:2596–2599
Ossipov DA, Hilborn J (2006) Macromolecules 39:1709–1718
Malkoch M, Vestberg R, Gupta N et al (2006) Chem Commun 2006:2774–6
Xu X-D, Chen C-S, Wang Z-C et al (2008) J Polym Sci A Polym Chem 46:5263–5277
Crescenzi V, Cornelio L, DiMeo C et al (2007) Biomacromolecules 8:1844–1850
Speers AE, Cravatt BF (2004) Chem & Biol 11:535–546
Johnson JA, Baskin JM, Bertozzi CR et al (2008) Chem Commun 2008:3064–3066
Sanborn TJ, Messersmith PB, Barron AE (2002) Biomaterials 23:2703–2710
Park H, Temenoff JS, Holland TA et al (2005) Biomaterials 26:7095–7103
Sperinde JJ, Griffith LG (1997) Macromolecules 30:5255–5264
Sperinde JJ, Griffith LG (2000) Macromolecules 33:5476–5480
McHale MK, Setton LA, Chilkoti A (2005) Tissue Eng 11:1768–1779
Au A, Ha J, Polotsky A et al (2003) J Biomed Mater Res A 67A:1310–1319
Raeber GP, Lutolf MP, Hubbell JA (2005) Biophys J 89:1374–1388
Kobayashi S, Uyama H, Kimura S (2001) Chem Rev 101:3793–3818
Sofia SJ, Singh A, Kaplan DL (2002) J Macromol Sci phys A39:1151–1181
Kurisawa M, Chung JE, Yang YY et al (2005) Chem Commun 2005:4312–4314
Jin R, Hiemstra C, Zhong Z et al (2007) Biomaterials 28:2791–2800
Ogushi Y, Sakai S, Kawakami K (2007) J Biosci Bioeng 104:30–33
Sakai S, Kawakami K (2007) Acta Biomater 3:495–501
Hideto T (2005) Macromol Biosci 5:569–597
de Jong SJ, De Smedt SC, Wahls MWC et al (2000) Macromolecules 33:3680–3686
De Jong SJ, van Eerdenbrugh B, van Nostrum CF et al (2001) J Contr Release 71:261–275
Lim DW, Choi SH, Park TG (2000) Macromol Rapid Comm 21:464–471
Hiemstra C, Zhong Z, Li L et al (2006) Biomacromolecules 7:2790–2795
Hiemstra C, Zhong Z, Dijkstra PJ et al (2005) Macromol Symp 224:119–132
Ruel-Gariepy E, Leroux J-C (2004) Eur J Pharm Biopharm 58:409–426
Khattak SF, Bhatia SR, Roberts SC (2005) Tissue Eng 11:974–983
Jeong B, Bae YH, Lee DS et al (1997) Nature 388:860–862
Jeong B, Lee KM, Gutowska A et al (2002) Biomacromolecules 3:865–868
Jeong B, Kim SW, Bae YH (2002) Adv Drug Deliv Rev 54:37–51
Klouda L, Mikos AG (2008) Eur J Pharm Biopharm 68:34–45
He C, Kim SW, Lee DS (2008) J Contr Release 127:189–207
Yu YB (2002) Adv Drug Deliv Rev 54:1113–1129
Yang J, Xu C, Wang C et al (2006) Biomacromolecules 7:1187–1195
Yang J, Xu C, Kopeckova P et al (2006) Macromol Biosci 6:201–209
Wang C, Stewart RJ, KopeCek J (1999) Nature 397:417–420
Wang C, Kopecek J, Stewart RJ (2001) Biomacromolecules 2:912–920
Xu C, Kopeček J (2008) Pharm Res 25:674–682
Xu C, Breedveld V, Kopecek J (2005) Biomacromolecules 6:1739–1749
Nowak AP, Breedveld V, Pakstis L et al (2002) Nature 417:424–428
Pakstis LM, Ozbas B, Hales KD et al (2004) Biomacromolecules 5:312–318
Uekama K, Hirayama F, Irie T (1998) Chem Rev 98:2045–2076
vandeManakker F, vanderPot M, Vermonden T et al (2008) Macromolecules 41:1766–1773
Kretschmann O, Choi SW, Miyauchi M et al (2006) Angew Chem Int Edit 45:4361–4365
Loethen S, Kim J-M, Thompson DH (2007) Polymer Rev 47:383–418
Wei H, He J, Sun L-g et al (2005) Eur Polymer J 41:948–957
Li J, Li X, Ni X et al (2006) Biomaterials 27:4132–4140
Yoon JJ, Chung HJ, Park TG (2007) J Biomed Mater Res A 83A:597–605
Cellesi F, Tirelli N, Hubbell JA (2004) Biomaterials 25:5115–5124
Kim MR, Park TG (2002) J Contr Release 80:69–77
Niu G, Zhang H, Song L et al (2008) Biomacromolecules 9:2621–2628
Robb SA, Lee BH, McLemore R et al (2007) Biomacromolecules 8:2294–2300
Lee JB, Yoon JJ, Lee DS et al (2004) J Biomater Sci Polymer Ed 15:1571–1583
Vermonden T, Fedorovich NE, van Geemen D et al (2008) Biomacromolecules 9:919–926
Chung HJ, Lee Y, Park TG (2008) J Contr Release 127:22–30
Seal BL, Panitch A (2006) Acta Biomater 2:241–251
Hayashi T (1994) Prog Polymer Sci 19:663–702
Ma L, Gao C, Mao Z et al (2003) Biomaterials 24:4833–4841
Gough JE, Scotchford CA, Downes S (2002) J Biomed Mater Res 61:121–130
Wissink MJB, Beernink R, Pieper JS et al (2001) Biomaterials 22:151–163
Kuijpers AJ, Engbers GHM, Krijgsveld J et al (2000) J Biomater Sci Polym Ed 11:225–243
Hoshikawa A, Nakayama Y, Matsuda T et al (2006) Tissue Eng 12:2333–2341
Park H, Temenoff JS, Tabata Y et al (2007) Biomaterials 28:3217–3227
Young S, Wong M, Tabata Y et al (2005) J Contr Release 109:256–274
Lee KY, Mooney DJ (2001) Chem Rev 101:1869–1880
Ahmed TAE, Dare EV, Hincke M (2008) Tissue Eng B: Rev 14:199–215
Fussenegger M, Meinhart J, Hobling W et al (2003) Ann Plast Surg 51:493–498
Ahmed TAE, Griffith M, Hincke M (2007) Tissue Eng 13:1469–1477
Dikovsky D, Bianco-Peled H, Seliktar D (2006) Biomaterials 27:1496–1506
Betre H, Setton LA, Meyer DE et al (2002) Biomacromolecules 3:910–916
Betre H, Ong SR, Guilak F et al (2006) Biomaterials 27:91–99
Lim DW, Nettles DL, Setton LA et al (2007) Biomacromolecules 8:1463–1470
Nettles DL, Kitaoka K, Hanson NA et al (2008) Tissue Eng A 14:1133–1140
Haider M, Cappello J, Ghandehari H et al (2008) Pharm Res 25:692–699
Laurent TC, Fraser JR (1992) FASEB J 6:2397–2404
Kawasaki K, Ochi M, Uchio Y et al (1999) J Cell Physiol 179:142–148
Tokita Y, Okamoto A (1995) Polymer Degrad Stabil 48:269–273
Nettles DL, Vail TP, Morgan MT et al (2004) Ann Biomed Eng 32:391–397
Chung C, Mesa J, Randolph MA et al (2006) J Biomed Mater Res A 77A:518–525
Onishi H, Machida Y (1999) Biomaterials 20:175–182
Moss JM, Van Damme M-PI, Murphy WH et al (1997) Arch Biochem Biophys 339:172–182
Francis Suh JK, Matthew HWT (2000) Biomaterials 21:2589–2598
Di Martino A, Sittinger M, Risbud MV (2005) Biomaterials 26:5983–5990
Kim I-Y, Seo S-J, Moon H-S et al (2008) Biotechnol Adv 26:1–21
Wu J, Su Z-G, Ma G-H (2006) Int J Pharm 315:1–11
Chenite A, Chaput C, Wang D et al (2000) Biomaterials 21:2155–2161
Bhattarai N, Ramay HR, Gunn J et al (2005) J Contr Release 103:609–624
Ono K, Saito Y, Yura H et al (2000) J Biomed Mater Res 49:289–295
Marsich E, Borgogna M, Donati I et al (2008) J Biomed Mater Res A 84A:364–376
Sechriest VF, Miao YJ, Niyibizi C et al (2000) J Biomed Mater Res 49:534–541
Hoemann CD, Sun J, Légaré A et al (2005) Osteoarthritis Cartilage 13:318–329
Kuo CK, Ma PX (2001) Biomaterials 22:511–521
Shoichet MS, Li RH, White ML et al (1996) Biotechnol Bioeng 50:374–381
Levesque SG, Lim RM, Shoichet MS (2005) Biomaterials 26:7436–7446
Levesque SG, Shoichet MS (2007) Bioconjug Chem 18:874–885
Van Tomme SR, Hennink WE (2007) Expert Rev Med Dev 4:147–164
Coviello T, Matricardi P, Marianecci C et al (2007) J Contr Release 119:5–24
Levesque SG, Shoichet MS (2006) Biomaterials 27:5277–5285
Suggs LJ, Shive MS, Garcia CA et al (1999) J Biomed Mater Res 46:22–32
Dadsetan M, Szatkowski JP, Yaszemski MJ et al (2007) Biomacromolecules 8:1702–1709
Suggs LJ, Payne RG, Yaszemski MJ et al (1997) Macromolecules 30:4318–4323
Shung AK, Behravesh E, Jo S et al (2003) Tissue Eng 9:243–254
Behravesh E, Jo S, Zygourakis K et al (2002) Biomacromolecules 3:374–381
Shin H, Quinten Ruh P, Mikos AG et al (2003) Biomaterials 24:3201–3211
Suggs LJ, Krishnan RS, Garcia CA et al (1998) J Biomed Mater Res 42:312–320
Temenoff JS, Park H, Jabbari E et al (2004) Biomacromolecules 5:5–10
Temenoff JS, Athanasiou KA, Lebaron RG et al (2002) J Biomed Mater Res 59:429–437
Tanahashi K, Mikos AG (2003) J Biomed Mater Res A 67A:1148–1154
Temenoff JS, Park H, Jabbari E et al (2004) J Biomed Mater Res A 70A:235–244
Lee HJ, Lee J-S, Chansakul T et al (2006) Biomaterials 27:5268–5276
He X, Jabbari E (2007) Biomacromolecules 8:780–792
Chau Y, Luo Y, Cheung ACY et al (2008) Biomaterials 29:1713–1719
Burdick JA, Anseth KS (2002) Biomaterials 23:4315–4323
Yang F, Williams CG, Wang D-a et al (2005) Biomaterials 26:5991–5998
Gallea S, Lallemand F, Atfi A et al (2001) Bone 28:491–498
Chung Y-I, Ahn K-M, Jeon S-H et al (2007) J Contr Release 121:91–99
Tessmar JK, Gopferich AM (2007) Adv Drug Deliv Rev 59:274–291
Endres M, Hutmacher DW, Salgado AJ et al (2003) Tissue Eng 9:689–702
Luginbuehl V, Wenk E, Koch A et al (2005) Pharm Res 22:940–950
Benya PD, Shaffer JD (1982) Cell 30:215–224
Wang DA, Williams CG, Yang F et al (2004) Adv Funct Mater 14:1152–1159
Wang D-A, Varghese S, Sharma B et al (2007) Nat Mater 6:385–392
Shin H, Jo S, Mikos AG (2003) Biomaterials 24:4353–4364
Park Y, Sugimoto M, Watrin A et al (2005) Osteoarthritis Cartilage 13:527–536
Burdick JA, Mason MN, Hinman AD et al (2002) J Contr Release 83:53–63
Elisseeff J, McIntosh W, Fu K et al (2001) J Orthop Res 19:1098–1104
Tabata Y, Miyao M, Inamoto T et al (2000) Tissue Eng 6:279–289
Hisatome T, Yasunaga Y, Yanada S et al (2005) Biomaterials 26:4550–4556
Park KH, Na K (2008) J Biosci Bioeng 106:74–79
Hu BH, Messersmith PB (2003) J Am Chem Soc 125:14298–14299
Yamaguchi N, Zhang L, Chae BS et al (2007) J Am Chem Soc 129:3040–3041
Seliktar D, Zisch AH, Lutolf MP et al (2004) J Biomed Mater Res A 68A:704–716
Gonen-Wadmany M, Oss-Ronen L, Seliktar D (2007) Biomaterials 28:3876–3886
Almany L, Seliktar D (2005) Biomaterials 26:2467–2477
Bryant SJ, Arthur JA, Anseth KS (2005) Acta Biomater 1:243–252
Lee H, Park TG (2009) J Biomed Mater Res A 88A:797–806
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Jin, R., Dijkstra, P.J. (2010). Hydrogels for Tissue Engineering Applications. In: Ottenbrite, R., Park, K., Okano, T. (eds) Biomedical Applications of Hydrogels Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5919-5_11
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