In Vitro and In Vivo Nonimaging Tests
The radioimmunoassay (RIA) method was first developed by S.A. Berson and R.S. Yalow in the late 1950s for the determination of insulin in human serum. The method is employed to determine numerous hormones, enzymes, antigens, and drugs in minute quantities (10–9 to 10–12 M) in human plasma in order to assess various disease conditions.
KeywordsPolycythemia Vera Pernicious Anemia Free Antigen Label Antigen Linear Standard Curve
- Chase GC, Rabinowitz JL. Principles of Radioisotope Methodology. 3rd ed. Minneapolis: Burgess; 1970.Google Scholar
- Moss AJ Jr, Dalrymple GV, Boyd CM, eds. Practical Radioimmunoassay. St Louis: Mosby; 1976.Google Scholar
- Odell WD, Daughaday WH, eds. Principles of Competitive Protein-Binding Assays. Philadelphia: Lippincott; 1974.Google Scholar
- Rothfeld B, ed. Nuclear Medicine In Vitro. Philadelphia: Lippincott; 1974.Google Scholar
- Thorell JI, Larson SM. Radioimmunoassay and Related Techniques. St Louis: Mosby; 1978.Google Scholar