Diffusion Tensor Imaging: Introduction and Applications to Brain Tumor Characterization

  • Sumei Wang
  • Sungheon Kim
  • Elias R. Melhem


Accurate diagnosis and grading of brain tumors are often crucial as the management and prognosis substantially differ depending on the type and grade of the tumor. Diffusion tensor magnetic resonance imaging (DTI) has been recently applied to brain tumor characterization. Various DTI metrics derived from the diffusion-weighted imaging data provide information about the orientation and architecture of tissue microstructure at the voxel level. This chapter provides a brief review on the basic principles of DTI and its clinical application in brain tumors. It also includes discussions on some practical issues to further improve the reliability and reproducibility of the method.


Brain Tumor Brain Metastasis Fractional Anisotropy Mean Diffusivity Diffusion Anisotropy 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Neuroradiology, Department of RadiologyHospital of the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Radiology, Center for Biomedical ImagingNew York University School of MedicineNew YorkUSA
  3. 3.Department of Diagnostic Radiology and Nuclear MedicineUniversity of Maryland School of MedicineBaltimoreUSA

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