Strategies for Treating Abnormal Lipid Profiles with Drugs

  • Neil J. Stone


For the past 50 years, cardiovascular diseases have been the leading killers of men and women in the industrialized world [1]. A major advance has been ­control of risk factors, habits, or traits that incline susceptible individuals to coronary heart disease (CHD). Prospectively gathered data from the Framingham Heart Study shows that for men and women who at age 50 have no major risk factors, the burden of CHD is very small [2]. However, for those who reach 50 years of age with risk factors, the event rates for CHD with a reduction in total life expectancy is correspondingly large. Not surprisingly, for those who have already sustained a coronary event, cardiovascular mortality in the absence of treatment is high. Analysis of published studies by Law et al. [3] showed that the rate, if untreated, is 5% per year after a first myocardial infarction (MI) and 10% per year after each subsequent MI. There is consistent evidence from multiple, randomized, placebo-controlled clinical trials (RPCCTs) that the treatment of elevated blood cholesterol, a major CHD risk factor, results in a clinically important outcome difference. For patients who have known CHD or are greatly at its risk, treatment with HMG Coa reductase inhibitors (statins) that lower low-density lipoprotein cholesterol (LDL-C) substantially (more than 30%) is associated with significant reductions in fatal and nonfatal CHD [4,5].


Coronary Heart Disease Coronary Heart Disease Risk Factor Cholesterol Absorption Inhibitor Total Life Expectancy High Dose Statin Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Neil J. Stone
    • 1
  1. 1.Department of Cardiology, Center for Vascular Disease, Feinberg School of MedicineNorthwestern University, Bluhm Cardiovascular Institute, Northwestern Memorial HospitalChicagoUSA

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