Stem Cell Origin of Brain Tumors

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 671)


The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation. Conversely, genes identified as regulators of developmental biology are relevant to tumor biology. This is particularly relevant in the context of brain tumors, where recent evidence is mounting that the origin of brain tumors, specifically gliomas, may represent dysfunctional developmental neurobiology. NSCs are increasingly being investigated as the cell type that originally undergoes malignant transformation—the cell of origin—and the evidence for this is discussed.


Epidermal Growth Factor Receptor Brain Tumor Glioma Cell Cancer Stem Cell Neural Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Division of NeurosurgeryUCSD Medical CenterSan DiegoUSA
  2. 2.Pediatric NeurosurgeryRady Children’s HospitalSan DiegoUSA

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