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Animal Models of Neurological Disease

  • Amol Shah
  • Tomas Garzon-Muvdi
  • Rohit Mahajan
  • Vincent J. Duenas
  • Alfredo Quiñones-Hinojosa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 671)

Abstract

The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study of neuropathophysiology. These models have been the source of a plethora of information, such as the importance of certain molecular mechanisms and genetic contributions in neurological disease. Additionally, animal models have been utilized in the discovery and testing of possible therapeutic treatments. Although most neurological diseases are still not yet completely understood and reliable treatment is lacking, animal models provide a major step in the right direction.

Keywords

Transgenic Mouse Cerebral Ischemia Middle Cerebral Artery Occlusion Amyloid Precursor Protein Global Cerebral Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Amol Shah
    • 1
  • Tomas Garzon-Muvdi
    • 2
  • Rohit Mahajan
    • 3
  • Vincent J. Duenas
    • 4
  • Alfredo Quiñones-Hinojosa
    • 5
  1. 1.UCSD School of MedicineSan DiegoUSA
  2. 2.Department of NeurosurgeryJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.College of MedicineUniversity of ToledoToledoUSA
  4. 4.Del E. Webb Neuroscience, Agingand Stem Cell Research CenterBurnham Institute for Regenerative MedicineLa JollaUSA
  5. 5.Department of NeurosurgeryNeuroscience and Cellular and Molecular Medicine, Johns Hopkins UniversityBaltimoreUSA

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