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Psychological Genetics: Understanding the Nature of Psychological Differences Through Etiology

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Handbook of Genomics and the Family

Part of the book series: Issues in Clinical Child Psychology ((ICCP))

Abstract

Questions about the roles of nature and nurture in human behavior have changed radically over time. Arguments about whether genes or environment play a role in human behavior have largely been resolved, with a well-documented role for both factors in the development of psychological and behavioral traits. Correspondingly, the nature of inquiry about genetic influences has changed, to instead focus on how genes exert their influences, with regard to the specific genes involved, the biological processes underlying their expression, and the environmental and psychological factors initiating these processes.

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REFERENCES

  • Achenbach, T. M. (1966). The classification of children’s psychiatric symptoms: A factor analytic study. Psychological Monographs, 80, 37.

    Google Scholar 

  • Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nature Genetics, 23, 185–188.

    Article  PubMed  Google Scholar 

  • Baker, L. A., Jacobson, K. C., Raine, A., Lozano, D. I., & Bezdjian, S. (2007). Genetic and environmental bases of childhood antisocial behavior: A multi-informant twin study. Journal of Abnormal Psychology, 116, 219–235.

    Article  PubMed  Google Scholar 

  • Barr, C. S., Schwandt, M., Lindell, S. G., Chen, S. A., Goldman, D., Suomi, S. J., et al. (2007). Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male Rhesus Macaques. Archives of General Psychiatry, 64, 369–376.

    Article  PubMed  Google Scholar 

  • Bergeman, C. S., Chipuer, H. M., Plomin, R., Pedersen, N. L., McClearn, G. E., Nesselroade, J. R., et al. (1993). Genetic and environmental effects on openness to experience, agreeableness, and conscientiousness: An adoption/twin study. Journal of Personality, 61, 159–179.

    Article  PubMed  Google Scholar 

  • Bruder, C. E. G., Piotrowski, A., Gijsbers, A. A. C. J., Andersson, R., Erickson, S., Diaz de StÃ¥hl, T. et al. (2008). Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. American Journal of Human Genetics, 82, 763–771.

    Article  PubMed  Google Scholar 

  • Buckholtz, J. W., Sust, S., Tan, H. Y., Mattay, V. S., Straub, R. E., Meyer-Lindenberg, A. et al. (2007). fMRI evidence for functional epistasis between COMT and RGS4. Molecular Psychiatry, 12, 893–895.

    Article  PubMed  Google Scholar 

  • Cannon, T. D., & Keller, M. C. (2006). Endophenotypes in the genetic analyses of mental disorders. Annual Review of Clinical Psychology, 2, 267–290.

    Article  PubMed  Google Scholar 

  • Cardno, A. G., Rijsdijk, F. V., Sham, P. C., & McGuffin, P. (2002). A twin study of genetic relationships between psychotic syndromes. American Journal of Psychiatry, 159, 539–545.

    Article  PubMed  Google Scholar 

  • Carroll, J. B. (1993). Human cognitive abilities: A survey of factor-analytical studies. New York: Cambridge University Press.

    Book  Google Scholar 

  • Caspi, A., McClay, J., Moffitt, T., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.

    Article  PubMed  Google Scholar 

  • Devlin, B., Daniels, M., & Roeder, K. (1997). The heritability of IQ. Nature, 388, 468–471.

    Article  PubMed  Google Scholar 

  • Dick, D. M., Aliev, F., Wang, J. C., Grucza, R. A., Schuckit, M., Kuperman, S., et al. (2008). Using dimensional models of externalizing psychopathology to aid in gene identification. Archives of General Psychiatry, 65, 310–318.

    Article  PubMed  Google Scholar 

  • D’Onofrio, B. M., Slutske, W. S., Turkheimer, E., Emery, R. E., Harden, K. P., Heath, A. C., et al. (2007). Intergenerational transmission of childhood conduct problems: A children of twins study. Archives of General Psychiatry, 64, 820–829.

    Article  PubMed  Google Scholar 

  • Eaves, L. J., Martin, N. G., Heath, A. C., Schieken, R., Meyer, J., Silberg, J., et al. (1997). Age changes in the causes of individual differences in conservatism. Behavior Genetics, 27, 121–124.

    Article  PubMed  Google Scholar 

  • Faraone, S. V., Doyle, A. E., Mick, E., & Biederman, J. (2001). Meta-analysis of the association between the 7-repeat allele of the dopamine D4 receptor gene and attention deficit hyperactivity disorder. American Journal of Psychiatry, 158, 1052–1057.

    Article  PubMed  Google Scholar 

  • Feinberg, M. E., Button, T. M. M., Neiderhiser, J. M., Reiss, D., & Hetherington, E. M. (2007). Parenting and adolescent antisocial behavior and depression: Evidence of genotype x parenting environment interaction. Archives of General Psychiatry, 64, 457–465.

    Article  PubMed  Google Scholar 

  • Flint, J., & Munafo, M. R. (2007). The endophenotype concept in psychiatric genetics. Psychological Medicine, 37, 163–180.

    Article  PubMed  Google Scholar 

  • Flint, J., Valdar, W., Shifman, S., & Mott, R. (2005). Strategies for mapping and cloning quantitative trait genes in rodents. Nature Reviews Genetics, 6, 271–286.

    Article  PubMed  Google Scholar 

  • Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., et al. (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences, 102, 10604–10609.

    Article  Google Scholar 

  • Fraley, R. C., & Roberts, B. W. (2005). Patterns of continuity: A dynamic model for conceptualizing the stability of individual differences in psychological constructs across the life course. Psychological Review, 112, 60–74.

    Article  PubMed  Google Scholar 

  • Fulker, D. W., Cherny, S. S., Sham, P. C., & Hewitt, J. K. (1999). Combined linkage and association sib-pair analysis for quantitative traits. American Journal of Human Genetics, 64, 259–267.

    Article  PubMed  Google Scholar 

  • Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636–645.

    Article  PubMed  Google Scholar 

  • Gottesman, I. I., & Shields, J. (1972). Schizophrenia and genetics: A twin study vantage point. New York: Academic Press.

    Google Scholar 

  • Gottesman, I. I., & Shields, J. (1973). Genetic theorizing and schizophrenia. British Journal of Psychiatry, 122, 15–30.

    Article  PubMed  Google Scholar 

  • Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146–152.

    Article  PubMed  Google Scholar 

  • Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D. et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400–403.

    Article  PubMed  Google Scholar 

  • Hill, W. G., Goddard, M. E., & Visscher, P. M. (2008). Data and theory point to mainly additive genetic variance for complex traits. PLoS Genetics, 4, 1–10.

    Article  Google Scholar 

  • Ioannidis, J. P. A., Ntzani, E. E., Trikalinos, T. A., & Contopoulos-Ioannidis, D. G. (2001). Replication validity of genetic association studies. Nature Genetics, 29, 306–309.

    Article  PubMed  Google Scholar 

  • Jang, K. L., Livesley, W. J., Angleitner, A., Riemann, R., & Vernon, P. A. (2002). Genetic and environmental influences on the covariance of facets defining the domains of the five-factor model of personality. Personality and Individual Differences, 33, 83–101.

    Article  Google Scholar 

  • Johnson, W., & Krueger, R. F. (2004). Genetic and environmental structure of adjectives describing the domains of the Big Five Model of personality: A nationwide US twin study. Journal of Research in Personality, 38, 448–472.

    Article  Google Scholar 

  • Keller, M. C., Coventry, W. L., Heath, A. C., & Martin, N. G. (2005). Widespread evidence for non-additive genetic variation in Cloninger’s and Eysenck’s personality dimensions using a twin plus sibling design. Behavior Genetics, 35, 707–721.

    Article  PubMed  Google Scholar 

  • Kendler, K. S., Czajkowski, N., Tambs, K., Torgersen, S., Aggen, S. H., Neale, M. C., et al. (2006). Dimensional representations of DSM-IV Cluster A personality disorders in a population-based sample of Norwegian twins: A multivariate study. Psychological Medicine, 36, 1583–1591.

    Article  PubMed  Google Scholar 

  • Kendler, K. S., Davis, C. G., & Kessler, R. C. (1997). The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: A family history study. British Journal of Psychiatry, 170, 541–548.

    Article  PubMed  Google Scholar 

  • Kendler, K. S., Jacobson, K. C., Prescott, C. A., & Neale, M. C. (2003). Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. American Journal of Psychiatry, 160, 687–695.

    Article  PubMed  Google Scholar 

  • Kendler, K. S., Prescott, C. A., Myers, J., & Neale, M. C. (2003). The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Archives of General Psychiatry, 60, 929–937.

    Article  PubMed  Google Scholar 

  • Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., et al. (2006). MAOA, maltreatment, and gene-environment interaction predicting children’s mental health: New evidence and a meta-analysis. Molecular Psychiatry, 11, 903–913.

    Article  PubMed  Google Scholar 

  • Koenig, L. B., McGue, M., & Iacono, W. G. (2008). Stability and change in religiousness during emerging adulthood. Developmental Psychology, 44, 532–543.

    Article  PubMed  Google Scholar 

  • Krueger, R. F., Hicks, B. M., & McGue, M. (2001). Altruism and antisocial behavior: Independent tendencies, unique personality correlates, distinct etiologies. Psychological Science, 12, 397–402.

    Article  PubMed  Google Scholar 

  • Krueger, R. F., & Markon, K. E. (2006). Reinterpreting comorbidity: A model-based approach to understanding and classifying psychopathology. Annual Review of Clinical Psychology, 2, 111–133.

    Article  PubMed  Google Scholar 

  • Laird, N. M., & Lange, C. (2006). Family-based designs in the age of large-scale gene-association studies. Nature Reviews Genetics, 7, 385–394.

    Article  PubMed  Google Scholar 

  • Li, D., Sham, P. C., Owen, M. J., & He, L. (2006). Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Human Molecular Genetics, 15, 2276–2284.

    Article  PubMed  Google Scholar 

  • Lipska, B. K., Mitkus, S., Caruso, M., Hyde, T. M., Chen, J. S., Vakkalanka, R., et al. (2006). RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity. Human Molecular Genetics, 15, 2804–2812.

    Article  PubMed  Google Scholar 

  • Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003). Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genetics, 33, 177–182.

    Article  PubMed  Google Scholar 

  • Lucas, R. E., Diener, E., Grob, A., Suh, E. M., & Shao, L. (2000). Cross-cultural evidence for the fundamental features of extraversion. Journal of Personality and Social Psychology, 79, 452–468.

    Article  PubMed  Google Scholar 

  • Luczak, S. E., Glatt, S. J., & Wall, T. J. (2006). Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. Psychological Bulletin, 132, 607–621.

    Article  PubMed  Google Scholar 

  • Lyons, M. J., True, W. R., Eisen, S. A., Goldberg, J., Meyer, J. M., Faraone, S. V., et al. (1995). Differential heritability of adult and juvenile antisocial traits. Archives of General Psychiatry, 52, 906–915.

    Article  PubMed  Google Scholar 

  • Markon, K. E., & Krueger, R. F. (2005). Categorical and continuous models of liability to externalizing disorders: A direct comparison in NESARC. Archives of General Psychiatry, 62, 1352–1359.

    Article  PubMed  Google Scholar 

  • Markon, K. E., Krueger, R. F., Bouchard, T. J., & Gottesman, I. (2002). Normal and abnormal personality traits: Evidence for genetic and environmental relationships in the Minnesota Study of Twins Reared Apart. Journal of Personality, 70, 661–694.

    Article  PubMed  Google Scholar 

  • Martin, N., Scourfield, J., & McGuffin, P. (2002). Observer effects and heritability of childhood attention-deficit hyperactivity disorder symptoms. British Journal of Psychiatry, 180, 260–265.

    Article  PubMed  Google Scholar 

  • McCartney, K., Harris, M. J., & Bernieri, E. (1990). Growing up and growing apart: A developmental meta-analysis of twin studies. Psychological Bulletin, 107, 226–237.

    Article  PubMed  Google Scholar 

  • Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., et al. (2008). Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. American Journal of Human Genetics, 82, 696–711.

    Article  PubMed  Google Scholar 

  • Nadder, T. S., Silberg, J. L., Rutter, M., Maes, H. H., & Eaves, L. J. (2001). Comparison of multiple measures of ADHD symptomatology: A multivariate genetic analysis. Journal of Child Psychology and Psychiatry, 42, 475–486.

    Article  PubMed  Google Scholar 

  • Nicodemus, K. K., Kolachana, B. S., Vakkalanka, R., Straub, R. E., Giegling, I., Egan, M. F., et al. (2007). Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: Influence on risk of schizophrenia. Human Genetics, 120, 889–906.

    Article  PubMed  Google Scholar 

  • Orr, H. T., & Zoghbi, H. Y. (2007). Trinucleotide repeat disorders. Annual Review of Neuroscience, 30, 575–621.

    Article  PubMed  Google Scholar 

  • Ott, J. (1989). Statistical properties of the haplotype relative risk. Genetic Epidemiology, 6, 127–130.

    Article  PubMed  Google Scholar 

  • O‘Donnell, W. T., & Warren, S. T. (2002). A decade of molecular studies of fragile X syndrome. Annual Review of Neuroscience, 25, 315–338.

    Article  PubMed  Google Scholar 

  • Plomin, R., & Daniels, D. (1987). Why are children in the same family so different from one another? Behavioral and Brain Sciences, 10, 1–60.

    Article  Google Scholar 

  • Reichborn-Kjennerud, T., Czajkowski, N., Neale, M. C., Orstavik, R. E., Torgersen, S., Tambs, K., et al. (2006). Genetic and environmental influences on dimensional representations of DSM-IV cluster C personality disorders: A population-based multivariate twin study. Psychological Medicine, 37, 645–653.

    Article  PubMed  Google Scholar 

  • Risch, N., & Merikangas, K. (1996). The future of genetics studies of complex human diseases. Science, 273, 1516–1517.

    Article  PubMed  Google Scholar 

  • Schinka, J. A., Town, T., Abdullah, L., Crawford, F. C., Ordorica, P. I., Francis, E., et al. (2002). A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. Molecular Psychiatry, 7, 224–228.

    Article  PubMed  Google Scholar 

  • Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., et al. (2007). Strong association of de novo copy number mutations with autism. Science, 316, 445–449.

    Article  PubMed  Google Scholar 

  • Sherman, D. K., McGue, M. K., & Iacono, W. G. (1997). Twin concordance for attention deficit hyperactivity disorder: A comparison of teachers’ and mothers’ reports. American Journal of Psychiatry, 154, 532–535.

    PubMed  Google Scholar 

  • Stallings, M. C., Corley, R. P., Dennehey, B., Hewitt, J. K., Krauter, K. S., Lessem, J. M., et al. (2005). A Genome-wide search for quantitative trait loci that influence antisocial drug dependence in adolescence. Archives of General Psychiatry, 62, 1042–1051.

    Article  PubMed  Google Scholar 

  • Tan, H., Chen, Q., Sust, S., Buckholtz, J. W., Meyers, J. D., Egan, M. F., et al. (2007). Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proceedings of the National Academy of Sciences, 104, 12536–12541.

    Article  Google Scholar 

  • Thompson, L. A., Detterman, D. K., & Plomin, R. (1991). Associations between cognitive abilities and scholastic achievement: Genetic overlap but environmental differences. Psychological Science, 2, 158–165.

    Article  Google Scholar 

  • Turkheimer, E. (1998). Heritability and biological explanation. Psychological Review, 105, 782–791.

    Article  PubMed  Google Scholar 

  • Turkheimer, E. (2000). Three laws of behavior genetics and what they mean. Current Directions in Psychological Science, 9, 160–164.

    Article  Google Scholar 

  • Turkheimer, E., & Gottesman, I. I. (1991). Is H2 = 0 a null hypothesis anymore? Behavioral and Brain Sciences, 14, 410–411.

    Article  Google Scholar 

  • Turkheimer, E., Haley, A., Waldron, M., D’Onofrio, B., & Gottesman, I. I. (2003). Socioeconomic status modifies heritability of IQ in young children. Psychological Science, 14, 623–628.

    Article  PubMed  Google Scholar 

  • Turkheimer, E., & Waldron, M. C. (2000). Nonshared environment: A theoretical, methodological, and quantitative review. Psychological Bulletin, 126, 78–108.

    Article  PubMed  Google Scholar 

  • Tuvblad, C., Grann, M., & Lichtenstein, P. (2006). Heritability for adolescent antisocial behavior differs with socioeconomic status: Gene-environment interaction. Journal of Child Psychology and Psychiatry, 47, 734–743.

    Article  PubMed  Google Scholar 

  • Valdar, W., Solberg, L. C., Gauguier, D., Burnett, S., Klenerman, P., Cookson, W. O. et al. (2006). Genome-wide genetic association of complex traits in heterogeneous stock mice. Nature Genetics, 38, 879–887.

    Article  PubMed  Google Scholar 

  • Van Steen, K., McQueen, M. B., Herbert, A., Raby, B., Lyon, H., DeMeo, D. L., et al. (2005). Genomic screening and replication using the same data set in family-based association testing. Nature Genetics, 37, 683–691.

    Article  PubMed  Google Scholar 

  • Visscher, P. M., Medland, S. E., Ferreira, M. A., Morley, K. I., Zhu, G., Cornes, B. K., et al. (2006). Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genetics, 2, 316–325.

    Article  Google Scholar 

  • Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., et al. (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science, 320, 539–543.

    Google Scholar 

  • Watson, D., & Clark, L. A. (1997). Extraversion and its positive emotional core. In R. Hogan, J. Johnson, & S. Briggs (Eds.), Handbook of personality psychology (pp. 767–793). San Diego, CA: Academic Press.

    Google Scholar 

  • Wolf, H., Angleitner, A., Spinath, F. M., Riemann, R., & Strelau, J. (2004). Genetic and environmental influences on the EPQ-RS scales: A twin study using self- and peer reports. Personality and Individual Differences, 37, 579–590.

    Article  Google Scholar 

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Markon, K.E. (2010). Psychological Genetics: Understanding the Nature of Psychological Differences Through Etiology. In: Tercyak, K. (eds) Handbook of Genomics and the Family. Issues in Clinical Child Psychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5800-6_2

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