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Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering and cell therapy

  • Zun Chang Liu
  • Thomas Ming Swi Chang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 670)

Abstract

Adult stem cells, especially isolated from bone marrow, have been extensively investigated in recent years. Studies focus on their multiple plasticity of transdifferentiating into various cell lineages and on their potential in cellular therapy in regenerative medicine. In many cases, there is the need for tissue engineering manipulation. Among the different approaches of stem cells tissue engineering, microencapsulation can immobilize stem cells to provide a favorable microenvironment for stem cells survival and functioning. Furthermore, microencapsulated stem cells are immunoisolated after transplantation. We show that one intraperitoneal injection of microencapsulated bone marrow stem cells can prolong the survival of liver failure rat models with 90% of the liver removed surgically. In addition to transdifferentiation, bone marrow stem cells can act as feeder cells. For example, when coencapsulated with hepatocytes, stem cells can increase the viability and function of the hepatocytes in vitro and in vivo.

Keywords

Stem Cell Mesenchymal Stem Cell Tissue Engineering Hepatocyte Growth Factor Adult Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Zun Chang Liu
    • 1
  • Thomas Ming Swi Chang
    • 1
  1. 1.Artificial Cells and Organs Research Centre, Departments of Physiology, Medicine and Biomedical Engineering, Faculty of MedicineMcGill UniversityMontrealCanada

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