The Cancer Biomedical Informatics Grid (caBIG): An Evolving Community for Cancer Research



This chapter describes the Cancer Biomedical Informatics Grid (caBIG®) project, a collaboration among the National Cancer Institute (NCI) and numerous discovery organizations, mostly NCI-designated cancer centers. The rationale for the caBIG® project opens the review, followed by description and analysis of the pilot phase (2004–2007). Changes in caBIG® as it transitions to an enterprise phase are evaluated. The chapter concludes with a review of important papers that either describe caBIG® components or are based on the initiative.


National Cancer Institute Cancer Center Pilot Phase Biomedical Informatics Common Data Element 


  1. Amin W, Parwani AV, Schmandt L, Mohanty SK, Farhar G, Pople AK, Winters SB, Whelan NB, Schneider AM, Milnes JT, Valdivieso A, Feldman M, Pass HI, Dhir R, Melamed J, Becich MJ (2008) National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational research. BMC Cancer 8:236PubMedCrossRefGoogle Scholar
  2. Beck JR, Bondy JC (2007) The cancer biomedical informatics grid (caBIG): infrastructure and applications for a worldwide research community. Stud Health Technol Inform 129:330–334Google Scholar
  3. Buetow KH (2005) Cyberinfrastructure: empowering a “third way” in biomedical research. Science 308:821–824PubMedCrossRefGoogle Scholar
  4. Buetow KH (2009) An infrastructure for interconnecting research institutions. Drug Discov Today 14:605–610PubMedCrossRefGoogle Scholar
  5. Channin DS, Mongkolwat P, Kleper V, Sepukar K, Rubin DL (2009) The caBIG annotation and image markup project. J Digital Imag (in press)Google Scholar
  6. Cimino JJ, Hayamizu TF, Bodenreider O, Davis B, Stafford GA, Ringwald M (2009) The caBIG terminology review process. J Biomed Inform. doi: 10.1016/j.jbi.2008.12.003
  7. Freimuth RR, Schauer MW, Lodha P, Govindrao P, Nagarajan R, Chute CG (2008) caBIG compatibility review system: software to support the evaluation of applications using defined interoperability criteria. AMIA Annu Symp Proc 197–201Google Scholar
  8. Fridsma DB, Evans J, Hastak S, Mead CN (2008) The BRIDG Project: A technical report. J Am Med Inform Assoc 15:130–137PubMedCrossRefGoogle Scholar
  9. Gurcan MN, Pan T, Sharma A, Kurc T, Oster S, Langella S, Hastings S, Siddiqui KM, Siegel EL, Saltz J (2007) GridIMAGE: a novel use of grid computing to support interactive human and computer-assisted detection decision support. J Digit Imaging 20:160–171PubMedCrossRefGoogle Scholar
  10. Hanash S (2004) Integrated global profiling of cancer. Nat Rev Cancer 4:638–643PubMedCrossRefGoogle Scholar
  11. Huang T, Shenoy PJ, Sinha R, Graiser M, Bumpers KW, Flowers CR (2009) Development of the Lymphoma Enterprise Architecture Database: a caBIG silver level compliant system. Cancer Inform 8:45–64PubMedGoogle Scholar
  12. Kaiser J (2004) Von Eschenbach revises the NCI agenda. Science 303:1952PubMedCrossRefGoogle Scholar
  13. Kunz I, Lin M-C, Frey L (2009) Metadata mapping and reuse in caBIG. BMC Bioinformatics 10(S2):S4PubMedCrossRefGoogle Scholar
  14. Langella S, Oster S, Hastings S, Siebenlist F, Phillips J, Ervin D, Permar J, Kurc T, Saltz J (2007) The cancer biomedical informatics grid (caBIG) security infrastructure. AMIA Annu Symp Proc 433–437Google Scholar
  15. Madhaven S, Zenklusen JC, Kotliarov Y, Sahni H, Fine HA, Buetow K (2009) Rembrandt: helping personalized medicine become a reality through integrative translational research. Mol Cancer Res 7:157–167CrossRefGoogle Scholar
  16. Manion FJ, Robbins RJ, Weems WA, Crowley RS (2009) Security and privacy requirements for a multi-institutional cancer research data grid: an interview-based study. BMC Med Inform Decis Mak 9:31PubMedCrossRefGoogle Scholar
  17. McConnell P, Dash RC, Chilukuri R, Pietrobon R, Johnson K, Annechiarico R, Cuticchia AJ (2008) The cancer translational research informatics platform. BMC Med Inform Decis Mak 8:60PubMedCrossRefGoogle Scholar
  18. National Cancer Institute. The caBIG Pilot Phase: Report: 2003-2007. Accessed 3 Jan 2009
  19. Phillips J, Chilukuri R, Fragoso G, Warzel D, Covitz PA (2006) The caCORE software development kit: streamlining construction of biomedical information services. BMC Biomed Inform Decis Mak 6:2CrossRefGoogle Scholar
  20. Prior FW, Erickson BJ, Tarbox L (2007) Open source software projects of the caBIG in vivo imaging workspace software special interest group. J Digit Imaging 20(S1):94–100PubMedCrossRefGoogle Scholar
  21. Saltz J, Oster S, Hastings S, Langella S, Kurc T, Sanchez W, Kher M, Manisundaram A, Shanbhag K, Covitz P (2006) caGrid: design and implementation of the core architecture of the cancer biomedical informatics grid. Bioinformatics 22:1910–1916PubMedCrossRefGoogle Scholar
  22. Shironoshita EP, Jean-Mary YR, Bradley RM, Kabuka MR (2008) semCDI: a query formulation for semantic data integration in caBIG. J Am Med Inform Assoc 15:559–568PubMedCrossRefGoogle Scholar
  23. Tchuvatkina O, Shimoni L, Ochs MF, Moloshok T (2006) Proteomics LIMS: a caBIG project, year 1. AMIA Annu Symp Proc 1116Google Scholar
  24. Tobias J, Chilukuri R, Komatsoulis GA, Mohanty S, Sioutos N, Warzel DB, Wright LW, Crowley RS (2006) The CAP cancer protocols – a case study of caCORE based data standards implementation to integrate with the cancer biomedical informatics grid. BMC Med Inform Decis Mak 6:25PubMedCrossRefGoogle Scholar
  25. Zhu Y, Wang Z, Feng Y, Xuan J, Miller DJ, Hoffman EP, Wang Y (2006) Phenotypic-specific gene module discovery using a diagnostic tree and caBIG VISDA. Conf Proc IEEE Eng Med Biol Soc 1:5767–5770PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA

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