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Gene Therapy for Leukemia and Lymphoma

  • Xiaopei Huang
  • Yiping Yang
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 4)

Abstract

With the advancement of knowledge in immunology and virology, technological improvement in the transduction efficiency of existing viral vectors, and the development of new viral vectors in the past two decades, gene therapy targeting diseases at a molecular level has emerged as an exciting and promising strategy for treating hematolymphoid malignancies. Gene therapy is aimed to correct disease processes by introducing a functional gene into target cells to restore or modify cellular functions. Unlike conventional therapies for treating cancers, gene therapy, in theory, could deliver precise, malignancy-specific treatment with minimal side effects on normal cells and biological processes. For many patients with hematolymphoid malignancies who cannot benefit from the therapies available today, gene therapy may hold the promise of future treatment.

Keywords

Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Costimulatory Molecule Anaplastic Large Cell Lymphoma Chronic Lymphocytic Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Xiaopei Huang
    • 1
  • Yiping Yang
    • 1
  1. 1.Department of Medicine and ImmunologyDuke University Medical CenterDurhamUSA

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