Molecular Pathology of Infectious Lymphadenitides

  • Kristin Fiebelkorn
Part of the Molecular Pathology Library book series (MPLB, volume 4)


In its role in the presentation of foreign antigens to the immune system, the lymph node is frequently involved in both local and systemic infections. This may manifest as lymphadenopathy with reactive changes or localized infectious lymphadenitis, with or without necrosis and granulomatous inflammation, depending on the infectious agent. The vast majority of these infections are routinely diagnosed using nonmolecular methods, including culture, serology, and antigen testing. However, in some cases, other methods may be unavailable, or the presentation and appearance may be atypical, and direct confirmation of the infecting agent by in situ hybridization (ISH) or amplified nucleic acid detection is desired in the lymph node tissue itself.


Internal Transcribe Spacer Polymerase Chain Reaction Assay FFPE Tissue Nest Polymerase Chain Reaction Assay Kimura Disease 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Kristin Fiebelkorn
    • 1
  1. 1.Department of PathologyThe University of Texas Health Science Center at San AntonioSan AntonioUSA

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