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Sarcoidosis: Are There Sarcoidosis Genes?

  • Helmut H. Popper
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 4)

Abstract

More than 100 years have passed since the first description of sarcoidosis by Hutchinson and the identification of sarcoid granulomas by Besnier, Boeck, and Schaumann, but the causative agent or agents of sarcoidosis still have not been identified. However, in these intervening years, considerable knowledge has accumulated about the pathogenesis and the molecular events that lead to the granulomatous reaction. Clinical evaluation has shed some light on this systemic disease; pathology and immunology have contributed to our understanding of the inflammatory process. More recently, genetics and molecular biology have opened new avenues of research for this still enigmatic disease. There is some hope that new techniques provided by molecular biology, employing samples from bronchoalveolar lavage and biopsies, might elucidate the causative agents behind this disease and define the genetic modifications that make some people prone to developing sarcoidosis.

Keywords

Human Leukocyte Antigen Costimulatory Molecule Human Leukocyte Antigen Class Epithelioid Cell Cardiac Sarcoidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Helmut H. Popper
    • 1
  1. 1.Department of PathologyMedical University of GrazGrazAustria

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