Molecular Genetics of Mature T/NK Neoplasms

  • John P. Greer
  • Utpal P. Davé
  • Nishitha Reddy
  • Christine M. Lovly
  • Claudio A. Mosse
Part of the Molecular Pathology Library book series (MPLB, volume 4)


The mature (postthymocyte; peripheral) T/natural killer (NK) lymphomas/leukemias represent 5–15% of all non-Hodgkin lymphoma (NHL) and vary according to geography. Peripheral T cell lymphoma, not otherwise specified (PTCL, NOS), is the most common type worldwide. There are more nodal presentations in Europe and North America, where the second most common types in each region are angioimmunoblastic T cell lymphoma (AITL) and anaplastic large cell lymphoma (ALCL), respectively. There is more extranodal disease in Asia, due to Epstein–Barr virus related NK/T lymphoma and human T cell leukemia virus (HTLV)-1 associated adult T cell leukemia/lymphoma (ATLL). With the exceptions of the indolent mycosis fungoides (MF) and the chemo-sensitive anaplastic lymphoma kinase (ALK)-positive ALCL, the prognosis in most peripheral T/NK neoplasms is poor, with a 5-year survival less than 30%. (Table 25.1)


Anaplastic Lymphoma Kinase Anaplastic Large Cell Lymphoma Mycosis Fungoides Anaplastic Lymphoma Kinase Fusion Blastic Plasmacytoid Dendritic Cell Neoplasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • John P. Greer
    • 1
  • Utpal P. Davé
    • 2
  • Nishitha Reddy
    • 3
  • Christine M. Lovly
    • 4
  • Claudio A. Mosse
    • 5
  1. 1.Department of Hematology/Stem Cell TransplantationVanderbilt University Medical CenterNashvilleUSA
  2. 2.Division of Hematology/OncologyVanderbilt University Medical CenterNashvilleUSA
  3. 3.Department of MedicineVanderbilt University Medical CenterNashvilleUSA
  4. 4.Department of Hematology and OncologyVanderbilt University School of MedicineNashvilleUSA
  5. 5.Department of PathologyVanderbilt University Medical Center and Nashville Veterans Administration Medical Center, Tennessee Valley Healthcare SystemsNashvilleUSA

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