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Detection of Resistance to Therapy in Hematolymphoid Neoplasms

  • Karen Weck
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 4)

Abstract

In the past several decades, treatment of hematolymphoid disorders has made dramatic strides. However, the presence or development of resistance to various chemotherapeutic agents is an important problem that affects response to therapy. Drug resistance can be either intrinsic to cancer cells or acquired while on therapy. In this chapter, the major molecular mechanisms of resistance to therapy in hematolymphoid disorders are discussed and techniques that are used to detect resistance to therapy are described. General markers of resistance to therapy, such as cytogenetic markers of resistance or functional assays to measure response to therapy, are not described in this chapter. Rather, this chapter focuses on the detection of specific molecular mechanisms of drug resistance due to the presence or alteration of a specific gene product.

Keywords

Chronic Myeloid Leukemia Resistance Mutation Imatinib Mesylate Internal Tandem Duplication MDR1 Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Karen Weck
    • 1
  1. 1.Departments of Pathology and Laboratory Medicine and GeneticsUniversity of North CarolinaChapel HillUSA

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