Kinetics of the Ventilatory and Metabolic Responses to Moderate-Intensity Exercise in Humans following Prior Exercise-Induced Metabolic Acidaemia

  • Susan A. Ward
  • Brian J. Whipp
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


As the time constant of the phase 2 (ø2) ventilatory response (τV'E) to moderate exercise (< lactate threshold, θL) is reduced by exogenous procedures that augment peripheral (carotid) chemosensitivity (hypoxia; chronic metabolic acidaemia), we examined whether an acute endogenous metabolic acidaemia had a similar effect. Six subjects completed two tests (A, B), each comprising two 6-min bouts separated by a 6-min “0” W recovery: A:- 90% θL, 90% θL; B:- supra-θL (50% between θL and peak V'O2), 90% θL. For Protocol A, the bout 2 sub-θL τV'E was similar to bout 1. However, for Protocol B, where the initial supra-θL metabolic acidaemia was still evident at the end of the subsequent sub-θL bout, the sub-θL τV'E was shorter; τV'E/τV'O2 and τV'E/τV'CO2 were reduced; and the transient end-tidal PO2undershoot was less marked. We conclude that an acute, endogenous metabolic acidaemia speeds ø2 V'E kinetics in moderate exercise, consistent with carotid chemoreception contributing to the tightness of arterial pH-CO2 regulation and the magnitude of the transient arterial hypoxaemia.


Carotid Body Moderate Exercise Peak Versus Watts Recovery Chemoreflex Sensitization 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PhysiologyHuman Bio-Energetics Research Centre, Crickhowell and University of California at Los AngelesLos AngelesUSA

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