Sleep Loss Reduces Respiratory Motor Plasticity

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


Sleep loss leads to deficits in neuroplasticity that underlie important physiological functions such as learning and memory. However, the influence of sleep loss on respiratory motor plasticity is unclear. In this study, we examined the influence of sleep loss on plasticity of upper airway motor outflow induced by repeated obstructive apneas. Here, we demonstrate that repeated airway obstructions, as experienced during obstructive apnea (OSA), induce a long-term enhancement of upper airway respiratory muscle activity, and that short-term sleep deprivation (6 hours) reduces the magnitude of this response. Our results suggest that respiratory motor plasticity may be reduced or minimized in disease conditions that are characterized by abnormal sleep disturbances (e.g., OSA).


Obstructive Sleep Apnea Sleep Deprivation Obstructive Sleep Apnea Patient Sleep Loss Normal Sleep 



This research was funded by grants from the National Science and Engineering Research Council of Canada (NSERC) and Canadian Institutes of Health Research (CIHR). Arash Tadjalli is grateful to NSERC for funding his PhD studies.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Cell and Systems BiologyUniversity of TorontoTorontoCanada
  2. 2.Department of PhysiologyUniversity of TorontoTorontoCanada

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