Sleep Loss Reduces Respiratory Motor Plasticity

  • Arash Tadjalli
  • John Peever
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


Sleep loss leads to deficits in neuroplasticity that underlie important physiological functions such as learning and memory. However, the influence of sleep loss on respiratory motor plasticity is unclear. In this study, we examined the influence of sleep loss on plasticity of upper airway motor outflow induced by repeated obstructive apneas. Here, we demonstrate that repeated airway obstructions, as experienced during obstructive apnea (OSA), induce a long-term enhancement of upper airway respiratory muscle activity, and that short-term sleep deprivation (6 hours) reduces the magnitude of this response. Our results suggest that respiratory motor plasticity may be reduced or minimized in disease conditions that are characterized by abnormal sleep disturbances (e.g., OSA).


Obstructive Sleep Apnea Sleep Deprivation Obstructive Sleep Apnea Patient Sleep Loss Normal Sleep 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was funded by grants from the National Science and Engineering Research Council of Canada (NSERC) and Canadian Institutes of Health Research (CIHR). Arash Tadjalli is grateful to NSERC for funding his PhD studies.


  1. Baker-Herman, T.L., Fuller, D.D., Bavis, R.W., Zabka, A.G., Golder, F.J., Doperalski, N.J., Johnson, R.A., Watters, J.J., and Mitchell, G.S. (2003) BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat. Neurosci. 7, 48–55.CrossRefPubMedGoogle Scholar
  2. Baker, T.L., and Mitchell, G.S. (2000) Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats. J. Physiol. 529 Pt 1, 215–219.CrossRefPubMedGoogle Scholar
  3. Boonstra, T.W., Stins, J.F., Daffertshofer, A., and Beek, P.J. (2007) Effects of sleep deprivation on neural functioning: An integrative review. Cell. Mol. Life. Sci. 64, 934–946.CrossRefPubMedGoogle Scholar
  4. Cirelli, C. (2002) Functional genomics of sleep and circadian rhythm: how sleep deprivation affects gene expression in the brain: A review of recent findings. J. Appl. Physiol. 92, 394–400.PubMedGoogle Scholar
  5. Golder, F.J., Ranganthan, L., Satriotomo, I., Hoffman, M., Lovett-Barr, M.R., Watters, J.J., Baker-Herman, T.L., and Mitchell G.S. (2008) Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation. J. Neurosci. 28, 2033–2042CrossRefPubMedGoogle Scholar
  6. Guzman-Marin, R., Ying, Z., Suntsova, N., Methippara, M., Bashir, T., Szymusiak, R., Gomez-Pinilla, F., and McGinty, D. (2006) Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats. J. Physiol. 575, 807–819.CrossRefPubMedGoogle Scholar
  7. McDermott, M., Hardy, M., Bazan, N., and Magee, J.C. (2006) Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus. J. Physiol. 570, 553–565.CrossRefPubMedGoogle Scholar
  8. McGuire, M., Tartar, J.L., Cao, Y., McCarley, R.W., White, D.P., Strecker, R.E., and Ling, L. (2008) Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors. J.Physiol. 586, 5215–5229.CrossRefPubMedGoogle Scholar
  9. Peigneux, P., Laureys, S., Delbeuck, X. and Maquet, P. (2001) Sleeping brain, learning brain. The role of sleep for memory systems. Neuroreport. 12, A111–124CrossRefPubMedGoogle Scholar
  10. White, D.P. (2005) Pathogenesis of obstructive and central sleep apnea . Am. J. Respir. Crit. Care. Med. 172, 1363–1370.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Cell and Systems BiologyUniversity of TorontoTorontoCanada
  2. 2.Department of PhysiologyUniversity of TorontoTorontoCanada

Personalised recommendations