Noradrenergic Control of Trigeminal Motoneurons in Sleep: Relevance to Sleep Apnea
Using rapid-eye-movement (REM) sleep as a model state, we sought to determine whether noradrenaline functions to strengthen upper airway muscle tone by amplifying glutamatergic excitation on to trigeminal motoneurons. We report that noradrenaline cannot trigger motoneuron excitability on its own, instead acting to facilitate glutamatergic motor excitation.
KeywordsObstructive Sleep Apnea Masseter Muscle Microdialysis Probe Motoneuron Excitability Phenylephrine Hydrochloride
This research was supported by funds from Canadian Institutes of Health Research (CIHR) and Natural Sciences and Engineering Research of Canada (NSERC). PS is the recipient of a CGS Scholarship from NSERC.
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