Adrenaline Modulates on the Respiratory Network Development

  • Morimitsu Fujii
  • Akiko Arata
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


Adrenaline regulates respiratory network, however, adrenergic contribution to the developing respiratory center has not well studied. Adrenaline application on embryonic day 17 medulla–spinal cord block preparations abolished non-respiratory activity and enhanced respiratory frequency. Phentolamine application on neonatal brainstem-spinal cord preparations that produced stable neonatal respiration resulted in respiratory destabilization. In E19 rat, adrenaline switched from enhancement to depression of the respiratory rhythm. Adrenaline modulated GABAergic synaptic transmission to respiratory neurons in late developmental stage. These results suggest that the involvement of central adrenergic modulation on the respiratory network maturation.


Respiratory Rhythm Respiratory Neuron Inspiratory Neuron Phrenic Nerve Activity Respiratory Network 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Laboratory for Memory & LearningRIKEN Brain Science InstituteWako CityJapan
  2. 2.Department of PhysiologyHyogo College of MedicineNishinomiyaJapan

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