Chemical Control of Airway and Ventilatory Responses Mediated Via Dorsomedial Medullary 5-HT2 Receptors

  • Mitsuko Kanamaru
  • Ikuo Homma
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


The airway and ventilatory responses in mice elicited by the inhalation of hypercapnic or hypoxic gas mixtures were investigated by a microdialysis technique, 5-HT release analysis and double-chamber plethysmography with or without 5-HT2 receptor activity in the dorsomedial medulla oblongata (DMM). Hypercapnia elicited compensatory airway dilation and additive ventilatory augmentation to 5-HT2 receptor activity in the DMM. Hypoxia mediated immediate onset of hypoxic hyperventilation and airway dilation, and subsequent hypoxic ventilatory decline. Chemical control of the airway and ventilatory responses mediated via 5-HT2 receptors in the DMM are reviewed.


Obstructive Sleep Apnea Obstructive Sleep Apnea Patient Ventilatory Response Solitary Tract Nucleus Hypoxic Ventilatory Response 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PhysiologyShowa University School of MedicineTokyoJapan

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