Central Respiratory Failure in a Mouse Model Depends on the Genetic Background of the Host

  • Satoru Arata
  • Kenji Amano
  • Kazuhiro Yamakawa
  • Akiko Arata
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


To define the mechanisms of human congenital central respiratory failure, we are examining gene-deficient mice with central respiratory failure. However, the influence of the genetic background of the mice may play an important role in the phenotype of the mice. Therefore, we examined developmental respiratory adaptation in several mouse strains. Neonatal mice from P0 to P3 were examined by whole-body plethysmography and the electro- physiological analysis using brainstem-spinal cord preparations. Our results show that respiratory maturation becomes progressively fixed after birth and that the rate of progression depends on the genetic background of the mice. In particular, the progression of C57BL/6 mice was delayed compared to that of BALB/c mice.


Down Syndrome Pulmonary Ventilation Respiratory Instability Syndrome Cell Adhesion Molecule Respiratory Rhythmogenesis 
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This work was partly supported a Showa University Grant-in Aid for Innovative Collaborative Research Projects and by a Grant-in-Aid for Scientific Research (c) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Satoru Arata
    • 1
  • Kenji Amano
    • 2
  • Kazuhiro Yamakawa
    • 3
  • Akiko Arata
    • 4
    • 5
  1. 1.Center for BiotechnologyShowa UniversityTokyoJapan
  2. 2.Laboratory for NeurogeneticsRIKEN Brain Science InstituteWako-shiJapan
  3. 3.Laboratory for NeurogeneticsRIKEN Brain Science Institute, HirosawaWako-shiJapan
  4. 4.Laboratory for Memory and LearningRIKEN Brain Science InstituteWako-shiJapan
  5. 5.Department of PhysiologyHyogo College of MedicineNishinomiyaJapan

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