Active Inspiratory-Expiratory Phase Switching Mechanism Exists in the Neonatal Nucleus Parabrachialis

  • Akiko Arata
  • Ikuko Tanaka
  • Morimitsu Fujii
  • Kazuhisa Ezure
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


The nucleus parabrachialis complex (NPB) which contained with nucleus parabrachialis lateralis, nucleus parabrachialis medialis and Kölliker-Fuse nucleus of the pons is known as a respiratory modulating center and the NPB plays a crucial role in the inspiratory off-switch (von Euler 1983; Feldman 1986; Bianchi et al. 1995; Alheid et al. 2004; Chamberlin 2004; Dutschmann et al. 2004, 2008). The NPB/KF complex is connected reciprocally to medullary respiratory groups, including the ventral respiratory column and the nucleus tractus solitarii, which serves as the first relay of afferents from pulmonary stretch receptors (Ezure 2004; Ezure and Tanaka 2006; Cohen and Shaw 2004).


Nucleus Tractus Solitarii Nucleus Parabrachialis Respiratory Neuron Phase Switching Trigeminal Nerve Root 
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  1. Aleksandrov, V.G., Aleksandrova, N.P., and Bagaev, V.A. (2000) Identification of a respiratory related area in the rat insular cortex. Can. J. Physiol. Pharmacol. 78, 582–586.CrossRefPubMedGoogle Scholar
  2. Alheid, G.F., Milsom, W.K., and McCrimmon, D.R. (2004) Pontine influences on breathing: an overview. Respir. Physiol. Neurobiol. 143, 105–114.CrossRefPubMedGoogle Scholar
  3. Arata, A., Onimaru, H., and Homma, I. (1990) Respiratory-related neurons in the ventral medulla of newborn rats in vitro. Brain Res. Bull. 24, 599–604.CrossRefPubMedGoogle Scholar
  4. Arata, A., Tanaka, I., and Ezure, K., (2000) Identification of pontine respiratory neurons in brain stem-spinal cord preparation from newborn rat. Neurosci. Res. Suppl. 24, S173.CrossRefGoogle Scholar
  5. Arata, A. (2009) Respiratory activity of the neonatal dorsolateral pons in vitro. Respir. Physiol. Neurobiol. 168, 144–152.CrossRefPubMedGoogle Scholar
  6. Bianchi, A.L., Denavit-Saubie, M., and Champagnat, J. (1995) Central control of breathing in mammals: Neuronal circuitry, membrane properties, and neurotransmitters. Physiol. Rev. 75, 1–45.PubMedGoogle Scholar
  7. Chamberlin, N.L. (2004) Functional organization of the parabrachial complex and intertrigeminal region in the control of breathing. Respir. Physiol. Neurobiol. 143, 115–125.CrossRefPubMedGoogle Scholar
  8. Cohen, M.I. and Shaw, C.F. (2004) Role in the inspiratory off-switch of vagal inputs to rostral pontine inspiratory-modulated neurons. Respir. Physiol. Neurobiol. 143, 127–140.CrossRefPubMedGoogle Scholar
  9. Dutschmann, M., Mörschel, M., Kron, M., and Herbert, H. (2004) Development of adaptive behaviour of the respiratory network: implications for the pontine Kolliker-Fuse nucleus. Respir. Physiol. Neurobiol. 143, 155–165.CrossRefPubMedGoogle Scholar
  10. Dutschmann, M., Mörschel, M., Reuter, J., Zhang, W., Gestreau, C., Stettner, G.M., and Kron, M. (2008) Postnatal emergence of synaptic plasticity associated with dynamic adaptation of the respiratory motor pattern. Respir. Physiol. Neurobiol. 164, 72–79.CrossRefPubMedGoogle Scholar
  11. Euler, C.Von. (1983) On the central pattern generator for the basic breathing rhythmicity. J. Appl. Physiol. 55, 1647–1659.Google Scholar
  12. Ezure, K. (2004) Respiration-related afferents to parabrachial pontine regions. Respir. Physiol. Neurobiol. 143, 167–175.CrossRefPubMedGoogle Scholar
  13. Ezure, K. and Tanaka, I. (2006) Distribution and medullary projection of respiratory neurons in the dorsolateral pons of the rat. Neuroscience 141, 1011–1023.CrossRefPubMedGoogle Scholar
  14. Farley, G.R., Barlow, S.M., and Netsell, R. (1992) Factors influencing neural activity in parabrachial regions during cat vocalizations. Exp. Brain Res. 89, 341–351.PubMedGoogle Scholar
  15. Feldman, J.L. (1986) Neurophysiology of breathing in mammals. In F.E. Bloom (Ed.), Handbook of physiology, section 1: The nervous system: Intrinsic Regulatory Systems in the Brain (pp. 463–524). Washington, DC: American Physiological Society.Google Scholar
  16. Jurgens, U. (2002) Neural pathways underlying vocal control. Neurosci. Biobehav. Rev. 26, 235–258.CrossRefPubMedGoogle Scholar
  17. Onimaru, H. and Homma, I. (1992) Whole cell recordings from respiratory neurons in the medulla of brainstem-spinal cord preparations isolated from newborn rats. Pflugers Arch. 420, 399–406.CrossRefPubMedGoogle Scholar
  18. Smotherman, M., Kobayasi, K., Ma, J., Zhang, S., and Metzner, W. (2006) A mechanism for vocal-respiratory coupling in the mammalian parabrachial nucleus. J. Neurosci. 26, 4860–4869.CrossRefPubMedGoogle Scholar
  19. Suzue, T. (1984) Respiratory rhythm generation in the in vitro brainstem-spinal cord preparation of the neonatal rat. J. Physiol. (Lond) 354, 173–183.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Akiko Arata
    • 1
    • 4
  • Ikuko Tanaka
    • 2
  • Morimitsu Fujii
    • 1
  • Kazuhisa Ezure
    • 3
  1. 1.Laboratory for Memory and LearningBrain Science Institute, RIKENSaitamaJapan
  2. 2.Department of Brain StructureTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  3. 3.School of NursingSaitama Medical UniversitySaitamaJapan
  4. 4.Department of PhysiologyHyogo College of MedicineHyogoJapan

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