Caffeine Reversal of Opioid-Evoked and Endogenous Inspiratory Depression in Perinatal Rat En Bloc Medullas and Slices

  • Araya Ruangkittisakul
  • Bogdan Panaitescu
  • Junya Kuribayashi
  • Klaus Ballanyi
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)


Caffeine counters endogenous or drug-evoked depression of breathing in (preterm) infants. Despite its common clinical use, little is known on central nervous mechanisms of its stimulatory respiratory action. We show that millimolar concentrations of caffeine are needed in perinatal rat en bloc medullas and medullary slices for stimulation of fictive inspiratory rhythms that were either endogenously slow in fetuses or depressed by prostagandins or opioids. Findings suggests that caffeine blocks phospodiesterase-4 thus raising cAMP in rhythmogenic pre-Bötzinger complex (preBötC) networks and/or cells driving the inspiratory preBötC.


Endogenous Depression Agonist DAMGO Medullary Slice Endogenous Neuromodulator Medullary Respiratory Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Supported by CIHR, AHFMR, CFI and ISRIP/ASRA. KB is a AHFMR Scientist. BP and AR have been awarded a CIHR studentship (MFN training grant).


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Araya Ruangkittisakul
    • 1
  • Bogdan Panaitescu
    • 1
  • Junya Kuribayashi
    • 1
  • Klaus Ballanyi
    • 1
  1. 1.Department of PhysiologyUniversity of AlbertaAlbertaCanada

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