Glycinergic Interneurons in the Respiratory Network of the Rhythmic Slice Preparation
The neuronal network in the pre-Bötzinger Complex is the key element of respiratory rhythm generation. Isolated in a slice preparation, the pre-Bötzinger Complex network is still able to generate its inspiratory activity. Although the mechanism of rhythm generation in principle relies on glutamatergic neurons, interestingly we found that glycinergic neurons represent a major portion of all inspiratory neurons in the slice preparation.
KeywordsBacterial Artificial Chromosome Enhance Green Fluorescent Protein Slice Preparation Enhance Green Fluorescent Protein Expression Current Clamp Recording
- Richter, D. (1996) Neural regulation of respiration: Rhythmogenesis and afferent control. In R. Gregor and U. Windhorst (Eds.), Comprehensive human physiology. Berlin: Springer-Verlag.Google Scholar
- Wallen-Mackenzie, A., Gezelius, H., Thoby-Brisson, M., Nygard, A., Enjin, A., Fujiyama, F., Fortin, G., and Kullander, K. (2006) Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation. J. Neurosci. 26, 12294–12307.CrossRefPubMedGoogle Scholar