Storage and Evolution of Memes in the Brain

Chapter

Abstract

Memes are portable memory and are stored in the brain. Short-term memory involves sensitization of synapses while long-term memory entails structural change of neurons through genetic engineering at the neuron level. Repeated synaptic stimulation activates a prion-like protein, CPEB, which activates mRNA to make protein for new synaptic growth and perpetuate it. Explicit memory involves consciousness and integration of potentiated neurons in the brain. Hippocampus is essential in converting short-term explicit memory into long-term. Learning fear involves potentiation of circuits involving amygdala. Working memory involves the temporary storage and manipulation of information necessary for the task at hand where the frontal cortex plays an important role. Memory (and thus meme) has been shown to be representable as a binary brain code representing activation of specific clusters of neurons. Such neural clusters representing memory undergo Darwinian evolution in the brain, forming the basis of evolution of memes in the brain. Thus, memes may become potentiated and dominant or attenuated and dormant. Dormant memes may be awakened by a fresh connection to newly introduced memes. Dreaming may serve an off-line meme-processing function.

Keywords

Depression Dopamine Recombination Schizophrenia Serotonin 

References

  1. Baddeley, A. (2000) The episodic buffer: A new component of working memory? Trends Cogn Sci, 4, 417–423.PubMedCrossRefGoogle Scholar
  2. Baddeley, A. (2001) The concept of episodic memory. Philos Trans R Soc Lond B Biol Sci, 356, 1345–1350.PubMedCrossRefGoogle Scholar
  3. Baddeley, A. (2003) Working memory and language: An overview. J Commun Disord, 36, 189–208.PubMedCrossRefGoogle Scholar
  4. Baddeley, A., Hitch, G. (1974) Working memory. In Recent Advances in Learning and Motivation (G. Bower ed.), pp. 47–90. Academic Press, New York.Google Scholar
  5. Bekinschtein, P., Cammarota, M., Katche, C., et al. (2008) BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci USA, 105, 2711–2716.PubMedCrossRefGoogle Scholar
  6. Bliss, T. V., Lomo, T. (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol, 232, 331–356.PubMedGoogle Scholar
  7. Drew, M. R., Hen, R. (2007) Adult hippocampal neurogenesis as target for the treatment of depression. CNS Neurol Disord Drug Targets, 6, 205–218.PubMedCrossRefGoogle Scholar
  8. Edelman, G. M. (1987) Neural Darwinism: The Theory of Neuronal Group Selection. Basic Books, New York.Google Scholar
  9. Edelman, G. M. (1993) Neural Darwinism: Selection and reentrant signaling in higher brain function. Neuron, 10, 115–125.PubMedCrossRefGoogle Scholar
  10. Edelman, G. M. (2004) Wider Than the Sky. Yale University Press, New Haven, CT.Google Scholar
  11. Goldman-Rakic, P. S., Castner, S. A., Svensson, T. H., et al. (2004) Targeting the dopamine D1 receptor in schizophrenia: Insights for cognitive dysfunction. Psychopharmacology (Berl), 174, 3–16.CrossRefGoogle Scholar
  12. Gould, E., McEwen, B. S., Tanapat, P., et al. (1997) Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci, 17, 2492–2498.PubMedGoogle Scholar
  13. Kandel, E. R. (2001) Psychotherapy and the single synapse: The impact of psychiatric thought on neurobiological research. 1979. J Neuropsychiatry Clin Neurosci, 13, 290–300; discussion 289.PubMedCrossRefGoogle Scholar
  14. Kandel, E. R. (2006) In Search of Memory: The Emergence of a New Science of Mind. W.W. Norton, New York.Google Scholar
  15. Kauer, J. A., Malenka, R. C., Nicoll, R. A. (1988) NMDA application potentiates synaptic transmission in the hippocampus. Nature, 334, 250–252.PubMedCrossRefGoogle Scholar
  16. Kondo, H., Morishita, M., Osaka, N., et al. (2004) Functional roles of the cingulo-frontal network in performance on working memory. Neuroimage, 21, 2–14.PubMedCrossRefGoogle Scholar
  17. Lin, L., Chen, G., Kuang, H., et al. (2007) Neural encoding of the concept of nest in the mouse brain. Proc Natl Acad Sci USA, 104, 6066–6071.PubMedCrossRefGoogle Scholar
  18. Lynch, G., Kessler, M., Arai, A., et al. (1990) The nature and causes of hippocampal long-term potentiation. Prog Brain Res, 83, 233–250.PubMedCrossRefGoogle Scholar
  19. Lynch, G., Muller, D., Seubert, P., et al. (1988) Long-term potentiation: Persisting problems and recent results. Brain Res Bull, 21, 363–372.PubMedCrossRefGoogle Scholar
  20. Monfils, M. H., Cowansage, K. K., LeDoux, J. E. (2007) Brain-derived neurotrophic factor: Linking fear learning to memory consolidation. Mol Pharmacol, 72, 235–237.PubMedCrossRefGoogle Scholar
  21. Pittenger, C., Duman, R. S. (2008) Stress, depression, and neuroplasticity: A convergence of mechanisms. Neuropsychopharmacology, 33, 88–109.PubMedCrossRefGoogle Scholar
  22. Reiser, M. (1991) Memory in Mind and Brain: What Dream Imagery Reveals. Yale University Press, New Haven, CT.Google Scholar
  23. Rogan, M. T., Leon, K. S., Perez, D. L., et al. (2005) Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse. Neuron, 46, 309–320.PubMedCrossRefGoogle Scholar
  24. Rudner, M., Ronnberg, J. (2008) The role of the episodic buffer in working memory for language processing. Cogn Process, 9, 19–28.PubMedCrossRefGoogle Scholar
  25. Sahay, A., Hen, R. (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci, 10, 1110–1115.PubMedCrossRefGoogle Scholar
  26. Shumyatsky, G. P., Malleret, G., Shin, R. M., et al. (2005) Stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell, 123, 697–709.PubMedCrossRefGoogle Scholar
  27. Shumyatsky, G. P., Tsvetkov, E., Malleret, G., et al. (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell, 111, 905–918.PubMedCrossRefGoogle Scholar
  28. Smith, E. E., Jonides, J. (1997) Working memory: A view from neuroimaging. Cognit Psychol, 33, 5–42.PubMedCrossRefGoogle Scholar
  29. Tsien, J. Z. (2007) Real-time neural coding of memory. Prog Brain Res, 165, 105–122.PubMedCrossRefGoogle Scholar
  30. Winson, J. (1985) Brain and Psyche: The Biology of the Unconscious. Doubleday, New York.Google Scholar
  31. Yoon, T., Okada, J., Jung, M. W., et al. (2008) Prefrontal cortex and hippocampus subserve different components of working memory in rats. Learn Mem, 15, 97–105.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York 2010

Authors and Affiliations

  1. 1.University of CaliforniaSan FranciscoUSA

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