Abstract
In North America, there are over 350,000 patients receiving hemodialysis for end stage renal disease (ESRD) [1, 2]. Reliable vascular access performance is necessary to ensure adequate dialysis, yet creating and maintaining functional accesses is both challenging and costly. For example, in 2008, ESRD only represented approximately 1% of the Medicare population but accounted for 24 billion dollars or 6–7% of Medicare expenditures. Hemodialysis accounted for 19.4 billion dollars, with access placement and complications estimated to contribute approximately 15% [3]. Of note, the costs of managing access events have increased by up to 17% over the past year [3].
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References
Canadian Organ Replacement Register. CORR report – treatment of end-stage organ failure in Canada, 1999 to 2008. Ottawa, ON: CORR; 2010.
U.S. Renal Data System. USRDS 2009 annual data report: atlas of chronic kidney disease and end-stage renal disease in the United States, National Institutes of Health, Fig. 6.4, Chap. 6. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases; 2009. p. 273.
U.S. Renal Data System. USRDS 2010 annual data report: atlas of chronic kidney disease and end-stage renal disease in the United States, National Institutes of Health. In: Costs of end-stage renal disease, vol. 2. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases; 2010.
Nosher JL. Death, taxes, and vascular access dysfunction. Semin Dial. 1991;4:67–8.
NIoHNaTNIoDaDaKD. Identification of factors associated with failure of arteriovenous fistulas to mature in hemodialysis patients (U01). Vol. 2010. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases; 2007.
Lok CE, Allon M, Donnelly S, Dorval M, et al. Design of the fish oil inhibition of stenosis in hemodialysis grafts (FISH) study. Clin Trials. 2007;4:357–67.
Conte MS, Nugent HM, Gaccione P, Guleria I, et al. Multicenter phase I/II trial of the safety of allogeneic endothelial cell implants after the creation of arteriovenous access for hemodialysis use: the V-HEALTH study. J Vasc Surg 2009; 50: 1359–1368 e1351.
Lee T, Roy-Chaudhury P. Advances and new frontiers in the pathophysiology of venous neointimal hyperplasia and dialysis access stenosis. Adv Chronic Kidney Dis. 2009;16:329–38.
Gimbrone Jr MA. Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Cardiol. 1995;75:67B–70.
Roy-Chaudhury P, Kelly BS, Miller MA, Reaves A, et al. Venous neointimal hyperplasia in polytetrafluoroethylene dialysis grafts. Kidney Int. 2001;59:2325–34.
Roy-Chaudhury P, Wang Y, Krishnamoorthy M, Zhang J, et al. Cellular phenotypes in human stenotic lesions from haemodialysis vascular access. Nephrol Dial Transplant. 2009;24:2786–91.
Anderson J, Abbuhl M, Hering T, Johnston K. Immunohistochemical identification of components in the healing response of human vascular grafts. ASAIO J. 1985;8:79–85.
Swedberg SH, Brown BG, Sigley R, Wight TN, et al. Intimal fibromuscular hyperplasia at the venous anastomosis of PTFE grafts in hemodialysis patients. Clinical, immunocytochemical, light and electron microscopic assessment. Circulation. 1989;80:1726–36.
Hehrlein C. How do AV fistulae lose function? The roles of haemodynamics, vascular remodelling, and intimal hyperplasia. Nephrol Dial Transplant. 1995;10:1287–90.
Golden MA, Au YP, Kenagy RD, Clowes AW. Growth factor gene expression by intimal cells in healing polytetrafluoroethylene grafts. J Vasc Surg. 1990;11:580–5.
Porter KE, Olojugba DH, Masood I, Pemberton M, et al. Endothelin-B receptors mediate intimal hyperplasia in an organ culture of human saphenous vein. J Vasc Surg. 1998;28:695–701.
Roy-Chaudhury P, Arend L, Zhang J, Krishnamoorthy M, et al. Neointimal hyperplasia in early arteriovenous fistula failure. Am J Kidney Dis. 2007;50:782–90.
Chang CJ, Ko PJ, Hsu LA, Ko YS, et al. Highly increased cell proliferation activity in the restenotic hemodialysis vascular access after percutaneous transluminal angioplasty: implication in prevention of restenosis. Am J Kidney Dis. 2004;43:74–84.
Wang Y, Krishnamoorthy M, Banerjee R, Zhang J, et al. Venous stenosis in a pig arteriovenous fistula model – anatomy, mechanisms and cellular phenotypes. Nephrol Dial Transplant. 2008;23:525–33.
Ombrellaro MP, Stevens SL, Schaeffer DO, Freeman MB, et al. The role of platelet-derived growth factor in intraluminal stented graft healing. J Am Coll Surg. 1997;184:49–57.
Faries PL, Marin ML, Veith FJ, Ramirez JA, et al. Immunolocalization and temporal distribution of cytokine expression during the development of vein graft intimal hyperplasia in an experimental model. J Vasc Surg. 1996;24:463–71.
Weiss MF, Scivittaro V, Anderson JM. Oxidative stress and increased expression of growth factors in lesions of failed hemodialysis access. Am J Kidney Dis. 2001;37:970–80.
Roselaar SE, Nazhat NB, Winyard PG, Jones P, et al. Detection of oxidants in uremic plasma by electron spin resonance spectroscopy. Kidney Int. 1995;48:199–206.
Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, Nguyen-Khoa T, et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int. 1996;49:1304–13.
Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int. 2002;62:1524–38.
Descamps-Latscha B, Goldfarb B, Nguyen AT, Landais P, et al. Establishing the relationship between complement activation and stimulation of phagocyte oxidative metabolism in hemodialyzed patients: a randomized prospective study. Nephron. 1991;59:279–85.
Zima T, Haragsim L, Stipek S, Bartova V, et al. Lipid peroxidation on dialysis membranes. Biochem Mol Biol Int. 1993;29:531–7.
Toborek M, Wasik T, Drozdz M, Klin M, et al. Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure. Metabolism. 1992;41:1229–32.
Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol. 1996;271:C1424–37.
Ruef J, Peter K, Nordt TK, Runge MS, et al. Oxidative stress and atherosclerosis: its relationship to growth factors, thrombus formation and therapeutic approaches. Thromb Haemost. 1999;82 Suppl 1:32–7.
Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86:494–501.
Stracke S, Konner K, Kostlin I, Friedl R, et al. Increased expression of TGF-beta1 and IGF-I in inflammatory stenotic lesions of hemodialysis fistulas. Kidney Int. 2002;61:1011–9.
Aviram M. LDL-platelet inteaction under oxidative stress induces macrophage foam cell formation. Thromb Haemost. 1997;74(1):560–4.
Fukai T, Folz RJ, Landmesser U, Harrison DG. Extracellular superoxide dismutase and cardiovascular disease. Cardiovasc Res. 2002;55:239–49.
Berk BC. Redox signals that regulate the vascular response to injury. Thromb Haemost. 1999;82:810–7.
Huynh TT, Davies MG, Trovato MJ, Barber L, et al. Reduction of lipid peroxidation with intraoperative superoxide dismutase treatment decreases intimal hyperplasia in experimental vein grafts. J Surg Res. 1999;84:223–32.
Lok CE, Allon A, Donnelly S, Dorval M, Hemmelgarn B, Moist L, et al. Design of the fish oil inhibition of stenosis in hemodialysis (FISH) Graft Study. Clin Trials. 2007;4(4):357–67.
Roy-Chaudhury P, Sukhatme VP, Cheung AK. Hemodialysis vascular access dysfunction: a cellular and molecular viewpoint. J Am Soc Nephrol. 2006;17:1112–27.
Dixon BS. Why don’t fistulas mature? Kidney Int. 2006;70:1413–22.
Dember LM, Beck GJ, Allon M, Delmez JA, et al. Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial. JAMA. 2008;299:2164–71.
Dixon BS, Beck GJ, Vazquez MA, Greenberg A, et al. The effect of dipyridamole plus aspirin on hemodialysis graft patency. N Engl J Med. 2009;360(21):2191–201.
Lok CE. Antiplatelet therapy and vascular-access patency. N Engl J Med. 2009;360:2240–2.
Schwab SJ, Raymond JR, Saeed M, Newman GE, et al. Prevention of hemodialysis fistula thrombosis. Early detection of venous stenoses. Kidney Int. 1989;36:707–11.
Besarab A, Sullivan KL, Ross RP, Moritz MJ. Utility of intra-access pressure monitoring in detecting and correcting venous outlet stenoses prior to thrombosis. Kidney Int. 1995;47:1364–73.
NKF-DOQI. Clinical practice guidelines for vascular access. National Kidney Foundation-Dialysis Outcomes Quality Initiative. Am J Kidney Dis. 1997;30:S150–91.
NKF-DOQI. Clinical practice guidelines for vascular access. Am J Kidney Dis. 2006;48:S176–247.
Hulley SB, Cummings SR, Browner WS, Grady D, Hearst N, Newman TB, editors. Designing clinical research. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 143–55.
Lok CE, Moist. LM. Challenges for randomized controlled trials in nephrology: illustrations in vascular access science and care. J Nephrol. 2007;20:632–45.
Gordis L. Epidemiology. 2nd ed. Philadelphia: W.B. Saunders; 2000. p. 100–9.
Besarab A. Access monitoring is worthwhile and valuable. Blood Purif. 2006;24:77–89.
Paulson WD, Work J. Controversial vascular access surveillance mandate. Semin Dial. 2010;23:92–4.
Abreo K, Allon M, Asif A, Atray N, et al. Which direction is right for vascular access surveillance? A debate. Nephrol News Issues. 2010;24:30, 32, 34.
Paulson WD. Access monitoring does not really improve outcomes. Blood Purif. 2005;23:50–6.
Sands JJ. Vascular access monitoring improves outcomes. Blood Purif. 2005;23:45–9.
White JJ, Bander SJ, Schwab SJ, Churchill DN, et al. Is percutaneous transluminal angioplasty an effective intervention for arteriovenous graft stenosis? Semin Dial. 2005;18:190–202.
Dember LM, Holmberg EF, Kaufman JS. Value of static venous pressure for predicting arteriovenous graft thrombosis. Kidney Int. 2002;61:1899–904.
McDougal G, Agarwal R. Clinical performance characteristics of hemodialysis graft monitoring. Kidney Int. 2001;60:762–6.
Paulson WD, Ram SJ, Birk CG, Work J. Does blood flow accurately predict thrombosis or failure of hemodialysis synthetic grafts? A meta-analysis. Am J Kidney Dis. 1999;34:478–85.
Paulson WD, Ram SJ, Birk CG, Zapczynski M, et al. Accuracy of decrease in blood flow in predicting hemodialysis graft thrombosis. Am J Kidney Dis. 2000;35:1089–95.
Ram SJ, Nassar R, Work J, Abreo K, et al. Risk of hemodialysis graft thrombosis: analysis of monthly flow surveillance. Am J Kidney Dis. 2008;52:930–8.
White JJ, Ram SJ, Jones SA, Schwab SJ, et al. Influence of luminal diameters on flow surveillance of hemodialysis grafts: insights from a mathematical model. Clin J Am Soc Nephrol. 2006;1:972–8.
Kheda MF, Brenner LE, Patel MJ, Wynn JJ, et al. Influence of arterial elasticity and vessel dilatation on arteriovenous fistula maturation: a prospective cohort study. Nephrol Dial Transplant. 2010;25:525–31.
Paulson WD, Asif A, Salman LH, Jones SA. Mathematical model of artriovenous fistula (AVF): a powerful method to improve understanding of the hemodynamics of AVF failure (abstract). J Am Soc Nephrol. 2010;21:248A.
White JJ, Jones SA, Ram SJ, Schwab SJ, et al. Mathematical model demonstrates influence of luminal diameters on venous pressure surveillance. Clin J Am Soc Nephrol. 2007;2:681–7.
Atray NK, Ram SJ, Work J, Eason JM, et al. A longitudinal study of hemodialysis graft stenosis: role of progressive stenosis in thrombosis (abstract). J Am Soc Nephrol. 2001;12:281A.
DeSoto DJ, Ram SJ, Faiyaz R, Birk CG, et al. Hemodynamic reproducibility during blood flow measurements of hemodialysis synthetic grafts. Am J Kidney Dis. 2001;37:790–6.
Ram SJ, Nassar R, Sharaf R, Magnasco A, et al. Thresholds for significant decrease in hemodialysis access blood flow. Semin Dial. 2005;18:558–64.
Schneditz D, Fan Z, Kaufman A, Levin NW. Stability of access resistance during haemodialysis. Nephrol Dial Transplant. 1998;13:739–44.
Rehman SU, Pupim LB, Shyr Y, Hakim R, et al. Intradialytic serial vascular access flow measurements. Am J Kidney Dis. 1999;34:471–7.
Agharazii M, Clouatre Y, Nolin L, Leblanc M. Variation of intra-access flow early and late into hemodialysis. ASAIO J. 2000;46:452–5.
Paulson WD, Ram SJ, Faiyaz R, Caldito GC, et al. Association between blood pressure, ultrafiltration, and hemodialysis graft thrombosis: a multivariable logistic regression analysis. Am J Kidney Dis. 2002;40:769–76.
Zasuwa G, Frinak S, Besarab A, Peterson E, et al. Automated intravascular access pressure surveillance reduces thrombosis rates. Semin Dial. 2010;23:527–35.
Dossabhoy NR, Ram SJ, Nassar R, Work J, et al. Stenosis surveillance of hemodialysis grafts by duplex ultrasound reduces hospitalizations and cost of care. Semin Dial. 2005;18:550–7.
Depner TA, Krivitski NM. Clinical measurement of blood flow in hemodialysis access fistulae and grafts by ultrasound dilution. ASAIO J. 1995;41:M745–9.
Krivitski NM. Theory and validation of access flow measurement by dilution technique during hemodialysis. Kidney Int. 1995;48:244–50.
Krivitski NM, MacGibbon D, Gleed RD, Dobson A. Accuracy of dilution techniques for access flow measurement during hemodialysis. Am J Kidney Dis. 1998;31:502–8.
Polkinghorne K. The CARI guidelines. Vascular access surveillance. Nephrology (Carlton). 2008;13 Suppl 2:S1–11.
Bos C, Smits JH, Zijistra JJ, Blankestijn PJ, et al. Underestimation of access flow by ultrasound dilution flow measurements. Phys Med Biol. 2002;47:481–9.
Sands J, Glidden D, Jacavage W, Jones B. Difference between delivered and prescribed blood flow in hemodialysis. ASAIO J. 1996;42:M717–9.
Tonelli M, James M, Wiebe N, Jindal K, et al. Ultrasound monitoring to detect access stenosis in hemodialysis patients: a systematic review. Am J Kidney Dis. 2008;51:630–40.
Allon M, Robbin ML. Hemodialysis vascular access monitoring: current concepts. Hemodial Int. 2009;13:153–62.
Paulson WD, White JJ. Should arteriovenous fistulas and synthetic grafts undergo surveillance with pre-emptive correction of stenosis? Nat Clin Pract Nephrol. 2008;4:480–1.
Levit RD, Cohen RM, Kwak A, Shlansky-Goldberg RD, et al. Asymptomatic central venous stenosis in hemodialysis patients. Radiology. 2006;238:1051–6.
Moist LM, Churchill DN, House AA, Millward SF, et al. Regular monitoring of access flow compared with monitoring of venous pressure fails to improve graft survival. J Am Soc Nephrol. 2003;14:2645–53.
Tessitore N, Bedogna V, Poli A, Mantovani W, et al. Adding access blood flow surveillance to clinical monitoring reduces thrombosis rates and costs, and improves fistula patency in the short term: a controlled cohort study. Nephrol Dial Transplant. 2008;23:3578–84.
Ram SJ, Nassar R, Work J, Eason JM, et al. Stenosis surveillance of hemodialysis grafts by Duplex Ultrasound reduces hospitalizations and cost of care. Semin Dial. 2005;18:550–7.
Kaegi A, Pineo GF, Shimizu A, Trivedi H, et al. Arteriovenous-shunt thrombosis. Prevention by sulfinpyrazone. N Engl J Med. 1974;290:304–6.
Harter HR, Burch JW, Majerus PW, Stanford N, et al. Prevention of thrombosis in patients on hemodialysis by low-dose aspirin. N Engl J Med. 1979;301:577–9.
Kobayashi K, Maeda K, Koshikawa S, Kawaguchi Y, et al. Antithrombotic therapy with ticlopidine in chronic renal failure patients on maintenance hemodialysis – a multicenter collaborative double blind study. Thromb Res. 1980;20:255–61.
Andrassy K, Malluche H, Bornefeld H, Comberg M, et al. Prevention of p.o. clotting of av. cimino fistulae with acetylsalicyl acid. Results of a prospective double blind study. Klin Wochenschr. 1974;52:348–9.
Grontoft KC, Mulec H, Gutierrez A, Olander R. Thromboprophylactic effect of ticlopidine in arteriovenous fistulas for haemodialysis. Scand J Urol Nephrol. 1985;19:55–7.
Sreedhara R, Himmelfarb J, Lazarus JM, Hakim RM. Anti-platelet therapy in graft thrombosis: results of a prospective, randomized, double-blind study. Kidney Int. 1994;45:1477–83.
Crowther MA, Clase CM, Margetts PJ, Julian J, et al. Low-intensity warfarin is ineffective for the prevention of PTFE graft failure in patients on hemodialysis: a randomized controlled trial. J Am Soc Nephrol. 2002;13:2331–7.
Kaufman JS, O’Connor TZ, Zhang JH, Cronin RE, et al. Randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosis. J Am Soc Nephrol. 2003;14:2313–21.
Schmitz PG, McCloud LK, Reikes ST, Leonard CL, et al. Prophylaxis of hemodialysis graft thrombosis with fish oil: double-blind, randomized, prospective trial. J Am Soc Nephrol. 2002;13:184–90.
Lumsden AB, MacDonald MJ, Kikeri D, Cotsonis GA, et al. Prophylactic balloon angioplasty fails to prolong the patency of expanded polytetrafluoroethylene arteriovenous grafts: results of a prospective randomized study. J Vasc Surg. 1997;26:382–90; discussion 390–382.
Ram SJ, Work J, Caldito GC, Eason JM, et al. A randomized controlled trial of blood flow and stenosis surveillance of hemodialysis grafts. Kidney Int. 2003;64:272–80.
Dember LM, Holmberg EF, Kaufman JS. Randomized controlled trial of prophylactic repair of hemodialysis arteriovenous graft stenosis. Kidney Int. 2004;66:390–8.
Malik J, Slavikova M, Svobodova J, Tuka V. Regular ultrasonographic screening significantly prolongs patency of PTFE grafts. Kidney Int. 2005;67:1554–8.
Robbin ML, Oser RF, Lee JY, Heudebert GR, et al. Randomized comparison of ultrasound surveillance and clinical monitoring on arteriovenous graft outcomes. Kidney Int. 2006;69:730–5.
Tessitore N, Mansueto G, Bedogna V, Lipari G, et al. A prospective controlled trial on effect of percutaneous transluminal angioplasty on functioning arteriovenous fistulae survival. J Am Soc Nephrol. 2003;14:1623–7.
Polkinghorne KR, Lau KK, Saunder A, Atkins RC, et al. Does monthly native arteriovenous fistula blood-flow surveillance detect significant stenosis–a randomized controlled trial. Nephrol Dial Transplant. 2006;21:2498–506.
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Paulson, W.D., Moist, L., Lok, C.E. (2011). Controversies in Vascular Access Monitoring and Surveillance. In: Rajan, D. (eds) Essentials of Percutaneous Dialysis Interventions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5657-6_4
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