Strategies and Implications for Prime-Boost Vaccination to Generate Memory CD8 T Cells

  • Jeffrey C. Nolz
  • John T. Harty
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 780)


Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against a variety of human diseases. Indeed, experimental models have demonstrated that the overall number of memory CD8 T cells present at the time of infection correlates strongly with the ability to confer host protection against a range of different pathogens. Currently, the most conceivable approach to rapidly generate a large population of memory CD8 T cells is through the use of prime-boost vaccination. In addition, recent experimental findings have uncovered important principles that govern both the rate and magnitude of memory CD8 T cell formation. Thus, this has resulted in novel prime-boost vaccination strategies that could potentially be used in humans to generate protective populations of memory CD8 T cells.


Human Immunodeficiency Virus Primary Vaccination Primary Memory High Endothelial Venule Booster Immunization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Businees Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Microbiology and Interdisciplinary Graduate Program in ImmunologyUniversity of IowaIowa CityUSA

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